ArticleProceedings of the National Academy of Sciences of the United States of America1988
pp60v-src tyrosine kinase is expressed and active in sarcoma-free avian embryos microinjected with Rous sarcoma virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 12 citations in OpenAlex.
- Platinum-sensitive recurrence in ovarian cancer: the role of tumor microenvironment.Frontiers in oncology · 2013Review
- Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes.Cold Spring Harbor symposia on quantitative biology · 2005Article
- Germ-line expression of an oncogenic erbB2 allele confers resistance to erbB2-induced mammary tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Tumor reversion: correction of malignant behavior by microenvironmental cues.International journal of cancer · 2003Review
- Expression of Rous sarcoma virus-derived retroviral vectors in the avian blastoderm: potential as stable genetic markers.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia.The Journal of cell biology · 1990Article
- v-src induces clonal sarcomas and rapid metastasis following transduction with a replication-defective retrovirus.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- The tumor microenvironment is a dominant force in multidrug resistance.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapyReview
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Early embryonic avian tissue is resistant to transformation by Rous sarcoma virus. To determine the nature of this resistance, we examined the expression and properties of the Rous sarcoma virus transforming protein pp60v-src, in infected embryonic chicken limbs in ovo. Lysates from Rous sarcoma virus-infected limbs contained the viral structural protein p19gag, as detected by immunoblot analysis, and showed pp60v-src kinase activity in vitro. Immunoblot analysis of lysates with anti-phosphotyrosine antibodies revealed a number of phosphotyrosine-containing proteins present in lysates of Rous sarcoma virus-infected embryos but not in lysates of control, uninfected embryos. Anti-phosphotyrosine immunoreactivity was observed in frozen sections in the same cell types that expressed pp60v-src and p19gag. These studies demonstrate that pp60v-src is co-expressed with viral structural determinants in infected embryonic avian tissue. Furthermore, pp60v-src is active in ovo as a tyrosine-specific phosphotransferase, despite the apparent lack of sarcoma induction. The localization pattern of the major src gene substrate p36 (calpactin I) was compared with that of p19gag by double-label immunofluorescence and found to be generally nonoverlapping. These observations are consistent with the concept that the induction of tumors in ovo requires complementation between viral determinants and host factors. These host factors, which may be critical substrates of pp60v-src, are subject to developmental regulation in the avian embryo.
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