SynthesisDepression and anxiety2017
Less is more: Patient-level meta-analysis reveals paradoxical dose-response effects of a computer-based social anxiety intervention targeting attentional bias.
Synthesis in Depression and anxiety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Effects of attention bias modification for anxiety: Neurophysiological indices and moderation by symptom severity.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Trial
- Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth.Behavior therapy · 2023Trial
- Attention bias modification augments cognitive-behavioral group therapy for social anxiety disorder: a randomized controlled trial.Psychological medicine · 2018Trial
- Attention Training for Child Anxiety and Its Disorders: Moving from Research to Clinical Implementation.Clinical child and family psychology review · 2024Review
- AttentionCARE: replicability of a BCI for the clinical application of augmented reality-guided EEG-based attention modification for adolescents at high risk for depression.Frontiers in human neuroscience · 2024Article
- Modification of Body-Related Attentional Bias through Virtual Reality and Eye-Tracking in Healthy Participants: Implications for Anorexia Nervosa Treatments.Brain sciences · 2023Article
- Distinct neural engagement during implicit and explicit regulation of negative stimuli.Neuropsychologia · 2020Article
- Computer-Assisted Cognitive-Behavior Therapy and Mobile Apps for Depression and Anxiety.Current psychiatry reports · 2019Review
- Attentional Bias Modification in Virtual Reality - A VR-Based Dot-Probe Task With 2D and 3D Stimuli.Frontiers in psychology · 2019Article
- Statistical learning as a predictor of attention bias modification outcome: A preliminary study among socially anxious patients.Behaviour research and therapy · 2019Article
- Attentional bias modification treatment for depression: Study protocol for a randomized controlled trial.Contemporary clinical trials · 2018Article
- Insula activation is modulated by attention shifting in social anxiety disorder.Journal of anxiety disorders · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe past decade of research has seen considerable interest in computer-based approaches designed to directly target cognitive mechanisms of anxiety, such as attention bias modification (ABM).
methodsBy pooling patient-level datasets from randomized controlled trials of ABM that utilized a dot-probe training procedure, we assessed the impact of training "dose" on relevant outcomes among a pooled sample of 693 socially anxious adults.
resultsA paradoxical effect of the number of training trials administered was observed for both posttraining social anxiety symptoms and behavioral attentional bias (AB) toward threat (the target mechanism of ABM). Studies administering a large (>1,280) number of training trials showed no benefit of ABM over control conditions, while those administering fewer training trials showed significant benefit for ABM in reducing social anxiety (P = .02). These moderating effects of dose were not better explained by other examined variables and previously identified moderators, including patient age, training setting (laboratory vs. home), or type of anxiety assessment (clinician vs. self-report).
conclusionsFindings inform the optimal dosing for future dot-probe style ABM applications in both research and clinical settings, and suggest several novel avenues for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.