ArticlePrenatal diagnosis2017
The validity of the observed-to-expected lung-to-head ratio in congenital diaphragmatic hernia in an era of standardized neonatal treatment; a multicenter study.
Article in Prenatal diagnosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Prenatal predictors of mortality in fetuses with congenital diaphragmatic hernia: a systematic review and meta-analysis.Pediatric surgery international · 2022Pooled it
- Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia.The New England journal of medicine · 2021Trial
- Fetal Pulmonary Vascular Assessment and Its Association with Postnatal Ductus Arteriosus Flow in Infants with a Congenital Diaphragmatic Hernia.Fetal diagnosis and therapy · 2026Article
- Three-dimensional MRI reconstruction of diaphragmatic defects in fetuses with congenital diaphragmatic hernia and mortality prediction.European radiology · 2026Article
- Early postnatal right-to-left patent ductus arteriosus shunting and severe outcomes in neonates with congenital diaphragmatic hernia: a retrospective cohort study.BMC pediatrics · 2025Article
- A machine learning approach to predict mortality and neonatal persistent pulmonary hypertension in newborns with congenital diaphragmatic hernia. A retrospective observational cohort study.European journal of pediatrics · 2025Observational
- Predicting outcomes with compounding comorbidities - Left-sided congenital diaphragmatic hernia complicated by pre-viable premature rupture of the membranes: A case report.Case reports in women's health · 2025Article
- Fetal MRI deep learning segmentation of body and lung in congenital diaphragmatic hernia.Radiology advances · 2025Article
- Prenatal Predictors of Survival in Isolated Congenital Diaphragmatic Hernia: A Systematic Review and Meta-analysis.O&G open · 2024Review
- Comparison of current to past outcomes in congenital diaphragmatic hernia using MRI observed-to-expected total fetal lung volume.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Pulmonary vasculature development in congenital diaphragmatic hernia: a novel automated quantitative imaging analysis.Pediatric surgery international · 2024Article
- The role of extracorporeal life support and timing of repair in infants with congenital diaphragmatic hernia.World journal of pediatric surgery · 2024Review
- Early echocardiographic pulmonary artery measurements as prognostic indicators in left congenital diaphragmatic hernia.BMC pediatrics · 2023Article
- Termination of pregnancy after a prenatal diagnosis of congenital diaphragmatic hernia: Factors influencing the parental decision process.Prenatal diagnosis · 2023Article
- Small prenatal diameter of the ascending aorta is associated with increased mortality risk in neonates with congenital diaphragmatic hernia.Archives of medical science : AMS · 2023Article
- Prenatal stomach position and volume in relation to postnatal outcomes in left-sided congenital diaphragmatic hernia.Prenatal diagnosis · 2022Article
- Spontaneous breathing approach in mild congenital diaphragmatic hernia: A resuscitation algorithm.Frontiers in pediatrics · 2022Article
- Fetal liver and lung volume index of neonatal survival with congenital diaphragmatic hernia.Pediatric radiology · 2021Article
- Management of Congenital Diaphragmatic Hernia (CDH): Role of Molecular Genetics.International journal of molecular sciences · 2021Review
- Unraveling the Genetics of Congenital Diaphragmatic Hernia: An Ongoing Challenge.Frontiers in pediatrics · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the predictive value of observed-to-expected lung-to-head ratio (O/E LHR) for survival and chronic lung disease (CLD) in survivors of left-sided congenital diaphragmatic hernia (CDH) in an era of standardized neonatal treatment, and to evaluate the predictive value of the O/E LHR trajectory for survival.
methodsThis retrospective cohort study was performed in two high-volume CDH centers in the Netherlands in prenatally detected, isolated left-sided CDH patients born between 2008 and 2014. O/E LHR and liver position were determined using 2D-ultrasonography at three time points during gestation from 19 weeks onwards. Ultrasound measurements were performed on stored ultrasound data by one single experienced operator blinded to postnatal outcome.
resultsOf the 122 included cases, 77.9% survived of whom 38.9% developed CLD. A significant association was found between the first measured O/E LHR and survival and development of CLD in survivors. Prenatal liver position did not have additional predictive value. No significant association was found between the trajectory of the O/E LHR and survival.
conclusionIn an era of standardized neonatal treatment for neonates with CDH, the first measured O/E LHR per patient significantly predicts survival and development of CLD in survivors in isolated left-sided CDH infants. © 2017 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.
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