ArticleGenome biology and evolution2017
Mitochondrial Genome Evolution and a Novel RNA Editing System in Deep-Branching Heteroloboseids.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Kingdom-wide evolutionary characterization of RNA editing factors in Archaeplastida.Molecular biology and evolution · 2026Article
- Quantifying genus-level divergence using 18S rDNA and its application to heterolobosea with discovery of a novel genus from Mombasa Kenya.Scientific reports · 2026Article
- Can transcriptome size and off-target effects explain the contrasting evolution of mitochondrial vs nuclear RNA editing?Journal of evolutionary biology · 2025Article
- Comparative analysis of mitochondrial genomes ofFrontiers in plant science · 2023Article
- Evolutionary diversification of the autophagy-related ubiquitin-like conjugation systems.Autophagy · 2022Article
- The closest lineage of Archaeplastida is revealed by phylogenomics analyses that includeOpen biology · 2022Article
- Single-cell genomics unveils a canonical origin of the diverse mitochondrial genomes of euglenozoans.BMC biology · 2021Article
- Evolutionary History of Mitochondrial Genomes in Discoba, Including the Extreme Halophile Pleurostomum flabellatum (Heterolobosea).Genome biology and evolution · 2021Article
- EukRef-excavates: seven curated SSU ribosomal RNA gene databases.Database : the journal of biological databases and curation · 2020Article
- Gene fragmentation and RNA editing without borders: eccentric mitochondrial genomes of diplonemids.Nucleic acids research · 2020Article
- Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- A single-cell genome reveals diplonemid-like ancestry of kinetoplastid mitochondrial gene structure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- PacBio-Based Mitochondrial Genome Assembly of Leucaena trichandra (Leguminosae) and an Intrageneric Assessment of Mitochondrial RNA Editing.Genome biology and evolution · 2018Article
- The genome of an intranuclear parasite,eLife · 2017Article
- Complete Mitochondrial Genomes of Ancyromonads Provide Clues for the Gene Content and Genome Structures of Ancestral Mitochondria.The Journal of eukaryotic microbiologyArticle
- A Deeply Branching Lineage in Heterolobosea (Discoba) With Multiflagellated and Multigrooved Life Stages.The Journal of eukaryotic microbiologyArticle
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5 authors.
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Abstract
Discoba (Excavata) is an evolutionarily important group of eukaryotes that includes Jakobida, with the most bacterial-like mitochondrial genomes known, and Euglenozoa, many of which have extensively fragmented mitochondrial genomes. However, little is known about the mitochondrial genomes of Heterolobosea, the third main group of Discoba. Here, we studied two heteroloboseids-an undescribed amoeba "BB2" and Pharyngomonas kirbyi. Phylogenomic analysis revealed that they form a clade that is a sister group to all other Heterolobosea. We characterized the mitochondrial genomes of BB2 and P. kirbyi, which encoded 44 and 48 putative protein-coding genes respectively. Their gene contents were similar to that of Naegleria. In BB2, mitochondrially encoded RNAs were heavily edited, with ∼500 mononucleotide insertion events, mostly guanosines. These insertions always have the same identity as an adjacent nucleotide. Editing occurs in all ribosomal RNAs and protein-coding transcripts except one, and half of the transfer RNAs. Analysis of Illumina deep-sequencing data suggested that this RNA editing is very accurate and efficient, and most likely co-transcriptional. The dissimilarity of this editing process to other RNA editing phenomena in discobids, as well as its apparent absence in P. kirbyi, suggest that this remarkably extensive system of insertional editing evolved independently in the BB2 lineage, after its divergence from the P. kirbyi lineage.
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