ArticleGenome biology and evolution2017
The Effects of CpG Densities around Transcription Start Sites on Sex-Biased Gene Expression in Poecilia reticulata.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- A genomic predictor for age at sexual maturity for mammalian species.Evolutionary applications · 2024Article
- Gender effects on autism spectrum disorder: a multi-site resting-state functional magnetic resonance imaging study of transcriptome-neuroimaging.Frontiers in neuroscience · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
As most genes are shared between females and males, DNA methylation is assumed to play a crucial role in sex-biased gene expression. DNA methylation exclusively occurs at CpG dinucleotides, and therefore, we would expect that CpG density around transcription start sites (TSSs) relate to sex-biased gene expression. Here we investigated the relationship between CpG densities around TSSs and the ratio of gene expression levels between sexes in the guppy (Poecilia reticulata), which displays remarkable sexual dimorphisms. We found that genes with sex-biased gene expression had different CpG densities downstream of TSSs compared with genes lacking sex-biased gene expression. Intriguingly, male-biased expression genes with intermediate CpG density downstream of TSSs exhibited greater differences in gene expression between sexes in the gonad and tail. Our findings suggested the possibility that CpGs around TSSs, especially in the downstream regions, play a crucial role in sex-biased gene expression through DNA methylation.
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