Observational studyAmerican journal of epidemiology2017
Time-Dependent Associations Between Body Composition, Physical Activity, and Current Asthma in Women: A Marginal Structural Modeling Analysis.
Observational study in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis.BMJ open respiratory research · 2024Pooled it
- Use of causal inference methods in case-control studies: a methodology review.American journal of epidemiology · 2026Review
- Plant-Based Diets and the Incidence of Asthma Symptoms among Elderly Women, and the Mediating Role of Body Mass Index.Nutrients · 2022Article
- Healthy diet associated with better asthma outcomes in elderly women of the French Asthma-E3N study.European journal of nutrition · 2022Article
- All Types Obesity and Physical Inactivity Associated with the Risk of Activity of Daily Living Limitations Among People with Asthma.Journal of multidisciplinary healthcare · 2022Article
- The Role of Nutritional Factors in Asthma: Challenges and Opportunities for Epidemiological Research.International journal of environmental research and public health · 2021Review
- The Effects of Obesity in Asthma.Current allergy and asthma reports · 2019Review
- DAG-informed regression modelling, agent-based modelling and microsimulation modelling: a critical comparison of methods for causal inference.International journal of epidemiology · 2019Article
- Influence of weight status in the response to Step-2 maintenance therapies in children with asthma.BMJ open respiratory research · 2019Article
- Association Between Vitamin D Metabolism Gene Polymorphisms and Risk of Tunisian Adults' Asthma.Lung · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of obesity in adult asthma is well-known and has been partly attributed to a confounding role of physical inactivity. However, the interrelationships between obesity, physical activity, and asthma have been incompletely addressed, probably because their time-dependent and bidirectional nature represents a methodologically challenging research question. We aimed to estimate the independent causal effects of body mass index (BMI; weight (kg)/height (m)2) and physical activity on current asthma using marginal structural models (MSMs). MSMs were applied to 15,353 adult women from a 2011 case-control study of asthma (Asthma-E3N) nested within the French E3N study (Etude Epidémiologique auprès de Femmes de la Mutuelle Générale de l'Education Nationale). Three time periods (1997-2000-2002, 2000-2002-2005, and 2002-2005-2011) were defined, where exposures (BMI and physical activity) were measured at time t, outcome (current asthma) was measured at time t + 1, and covariates were measured at time t - 1 or at baseline. A strong significant and positive dose-response relationship between BMI and current asthma was observed (odds ratios were 0.90 (95% confidence interval (CI): 0.79, 1.03), 1.29 (95% CI: 1.17, 1.42), and 1.87 (95% CI: 1.60, 2.18) for the BMI groups <20.0, 25.0-29.9, and ≥30.0, respectively, versus the normal-weight group (BMI 20.0-24.9)). We found no association between physical activity and current asthma. Our results suggest an independent causal deleterious effect of overweight and obesity on current asthma, whereas no independent causal effect of physical activity was found.
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Registered trials
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