ArticlePloS one2017
Effects of a mixture of chloromethylisothiazolinone and methylisothiazolinone on peripheral airway dysfunction in children.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration.Journal of Korean medical science · 2022Pooled it
- Exposures to humidifier disinfectant and various health conditions in Korean based on personal exposure assessment data of claimants for compensation.BMC public health · 2023Article
- Effects of stabilizer magnesium nirate on CMIT/MIT-induced respiratory toxicity.Toxicological research · 2023Article
- Reduced Diffusing Capacity in Humidifier Disinfectant-Associated Asthma Versus Typical Asthma: A Retrospective Case Control Study.Journal of Korean medical science · 2022Article
- Review of Inhalation Health Risks Involving Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT) Used as Disinfectants in Household Humidifiers.Journal of Korean medical science · 2022Review
- Children's exposures to boron and biocides from slime products in Asian regions.Journal of exposure science & environmental epidemiology · 2022Article
- Article
- The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children.Clinical and experimental pediatrics · 2020Article
- Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model.Scientific reports · 2020Article
- Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles.Molecules (Basel, Switzerland) · 2020Review
- Article
- Early-life exposure to humidifier disinfectant determines the prognosis of lung function in children.BMC pulmonary medicine · 2019Article
- Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium.Environmental health and toxicology · 2019Article
- Intra-nanogap controllable Au plates as efficient, robust, and reproducible surface-enhanced Raman scattering-active platforms.RSC advances · 2019Article
- Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury.Journal of Korean medical science · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren who were only exposed to a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) as humidifier disinfectant (HD) components were evaluated for humidifier disinfectant-associated lung injury (HDLI) from 2012. This study was to evaluate the pulmonary function using, impulse oscillometry (IOS) for children exposed to a mixture of CMIT/MIT from HD.
methodsTwenty-four children who were only exposed to a mixture of CMIT/MIT, with no previous underlying disease, were assessed by IOS. Diagnostic criteria for HDLI were categorized as definite, probable, possible, or unlikely. Home visits and administration of a standardized questionnaire were arranged to assess exposure characteristics.
resultsDefinite and probable cases showed higher airborne disinfectant exposure intensity during sleep (32.4 ± 8.7 μg/m3) and younger age at initial exposure (3.5 ± 3.3 months) compared with unlikely cases (17.3 ± 11.0 μg/m3, p = 0.026; 22.5 ± 26.2 months, p = 0.039, respectively). Reactance at 5 Hz was significantly more negative in those with high-density exposure during sleep (mean, -0.463 kPa/L/s vs. low density, -0.296, p = 0.001). The reactance area was also higher with high-density exposure during sleep (mean, 3.240 kPa/L vs. low density, 1.922, p = 0.039). The mean bronchodilator response with high-density exposure was within the normal range for reactance.
conclusionsSignificant peripheral airway dysfunction were found in children with high levels of inhalation exposure to a mixture of CMIT/MIT during sleep. Strict regulation of a mixture of CMIT/MIT exposure were associated with positive effects on lung function of children.
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