ArticlePloS one2017
A tool for discovering drug sensitivity and gene expression associations in cancer cells.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Integrative analysis of tumor-educated platelets for stage-specific diagnosis, prognosis, and therapy in ovarian cancer.Discover oncology · 2026Article
- Computational pipeline predicting cell death suppressors as targets for cancer therapy.iScience · 2024Article
- IDO1 correlates with the immune landscape of head and neck squamous cell carcinoma: a study based on bioinformatics analyses.Frontiers in oral health · 2024Article
- Single Cell Analysis of Gastric Cancer Reveals Non-Defined Telomere Maintenance Mechanism.Cells · 2022Article
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- The Matrisome Is Associated with Metabolic Reprograming in Stem-like Phenotypes of Gastric Cancer.Cancers · 2022Article
- CDK3, CDK5 and CDK8 Proteins as Prognostic and Potential Biomarkers in Colorectal Cancer Patients.International journal of general medicine · 2022Article
- The role of PDGFRA as a therapeutic target in young colorectal cancer patients.Journal of translational medicine · 2021Article
- Alternative lengthening of telomeres is mechanistically linked to potential therapeutic vulnerability in the stem-like subtype of gastric cancer.Clinical and translational medicine · 2021Article
- Chemotherapy confers a conserved secondary tolerance to EGFR inhibition via AXL-mediated signaling bypass.Scientific reports · 2021Article
- Pan-Cancer Analysis Reveals Distinct Metabolic Reprogramming in Different Epithelial-Mesenchymal Transition Activity States.Cancers · 2021Article
- A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications.BMC bioinformatics · 2021Article
- Effects of Gallotannin-Enriched Extract of Galla Rhois on the Activation of Apoptosis, Cell Cycle Arrest, and Inhibition of Migration Ability in LLC1 Cells and LLC1 Tumors.Pathology oncology research : POR · 2021Article
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- Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms.Science advances · 2020Article
- Elucidation of Mechanisms of Topotecan-Induced Cell Death in Human Breast MCF-7 Cancer Cells by Gene Expression Analysis.Frontiers in genetics · 2020Article
- Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4.Molecular cancer therapeutics · 2019Article
- PANOPLY: Omics-Guided Drug Prioritization Method Tailored to an Individual Patient.JCO clinical cancer informatics · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sensitivity of cancer cells to anticancer drugs is a crucial factor for developing effective treatments. However, it is still challenging to precisely predict the effectiveness of therapeutics in humans within a complex genomic and molecular context. We developed an interface which allows the user to rapidly explore drug sensitivity and gene expression associations. Predictions for how expression of various genes affect anticancer drug activity are available for all genes for a set of therapeutics based on data from various cell lines of different origin in the Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer projects. Our application makes discovery or validation of drug sensitivity and gene expression associations efficient. Effectiveness of this tool is demonstrated by multiple known and novel examples.
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