ArticleJournal of Alzheimer's disease : JAD2017
Cognitive Domain Dispersion Association with Alzheimer's Disease Pathology.
Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Associations of cognitive intraindividual variability with Alzheimer's disease risk: A systematic review.The Clinical neuropsychologist · 2026Pooled it
- Cognitive Intra-individual Variability in Cognitively Healthy APOE ε4 Carriers, Mild Cognitive Impairment, and Alzheimer's Disease: a Meta-analysis.Neuropsychology review · 2025Pooled it
- Cognitive dispersion is associated with white matter hyperintensities in amyloid positive older adults.The Clinical neuropsychologist · 2026Article
- Cognitive and Neuroimaging Biomarker Intra-Individual Variability in Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Global and domain-specific cognitive intraindividual variability associations with neurodegenerative diagnoses and postmortem pathologies.Alzheimer's research & therapy · 2026Article
- The Inflammatory Nexus: Unraveling Shared Pathways and Promising Treatments in Alzheimer's Disease and Schizophrenia.International journal of molecular sciences · 2025Review
- Characterizing Cognitive Dispersion and Its Correlates Across the Adult Lifespan in MIDUS.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Exploring the relationship between mean performance and within-person variability on smartphone-based cognitive testing in adults across the lifespan.NPP - digital psychiatry and neuroscience · 2025Article
- PET Imaging in Alzheimer Disease: Pathology and Research Insights for Technologists.Journal of nuclear medicine technology · 2024Review
- Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer's disease neuropathologic changes and cognitive decline.Acta neuropathologica · 2023Article
- Intraindividual Cognitive Variability and Magnetic Resonance Imaging in Aging American Indians: Data from the Strong Heart Study.Journal of Alzheimer's disease : JAD · 2023Article
- Personality predictors of cognitive dispersion: A coordinated analysis of data from seven international studies of older adults.Neuropsychology · 2022Article
- Longitudinal Intraindividual Cognitive Variability Is Associated With Reduction in Regional Cerebral Blood Flow Among Alzheimer's Disease Biomarker-Positive Older Adults.Frontiers in aging neuroscience · 2022Article
- Cognitive dispersion and ApoEe4 genotype predict dementia diagnosis in 8-year follow-up of the oldest-old.Age and ageing · 2021Article
- Cognitive variability, brain aging, and cognitive decline in late-life major depression.International journal of geriatric psychiatry · 2021Article
- Braak Stage, Cerebral Amyloid Angiopathy, and Cognitive Decline in Early Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Article
- Cognitive dispersion is a sensitive marker for early neurodegenerative changes and functional decline in nondemented older adults.Neuropsychology · 2019Article
- Cerebral Amyloid Angiopathy and Neuritic Plaque Pathology Correlate with Cognitive Decline in Elderly Non-Demented Individuals.Journal of Alzheimer's disease : JAD · 2019Article
- Cognitive composite score association with Alzheimer's disease plaque and tangle pathology.Alzheimer's research & therapy · 2018Article
- Cognitive dispersion is related to subtle objective daily functioning changes in older adults with and without cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Within neuropsychology, the term dispersion refers to the degree of variation in performance between different cognitive domains for an individual. Previous studies have demonstrated that cognitively normal individuals with higher dispersion are at an increased risk for progressing to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Therefore, we determined 1) whether increased dispersion in older adults was associated with amyloid plaques and neurofibrillary tangles (NFTs) and 2) whether increased cognitive dispersion accurately differentiated MCI and AD from non-cognitively impaired (NCI) individuals. The intra-subject standard deviation (ISD) was used to quantify cognitive dispersion, and receiver operator characteristic (ROC) analysis determined whether ISD differentiated MCI and AD from NCI. Neuropathological scores for diffuse plaques (DPs), neuritic plaques (NPs), and NFTs were used as outcome measures in a series of negative binomial regression models. Regression analyses found that increased ISD was associated with increased NFT pathology (β= 10.93, SE = 3.82, p = 0.004), but not with DPs (β= 1.33, SE = 8.85, p = 0.88) or NPs (β= 14.64, SE = 8.45, p = 0.08) after adjusting for age at death, gender, education, APOE ɛ4 status, and clinical diagnosis. An interaction term of ISD with age at death also showed a significant negative association (β= -0.13, SE = 0.04, p = 0.004), revealing an age-dependent association between ISD with NFTs. The ISD failed to show an acceptable level of diagnostic accuracy for MCI (AUC = 0.60). These findings suggest that increased cognitive dispersion is related to NFT pathology where age significantly affects this association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.