ArticleCancer biomarkers : section A of Disease markers2017
High expression of LAMP2 predicts poor prognosis in patients with esophageal squamous cell carcinoma.
Article in Cancer biomarkers : section A of Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 23 citations in OpenAlex.
- TAPI-1 Exhibits Anti-tumor Efficacy in Human Esophageal Squamous Cell Carcinoma Cells via Suppression of NF-κB Signaling Pathway.Digestive diseases and sciences · 2024Article
- Ferroptosis Markers Predict the Survival, Immune Infiltration, and Ibrutinib Resistance of Diffuse Large B cell Lymphoma.Inflammation · 2022Article
- Chaperone-mediated autophagy affects tumor cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma.Thoracic cancer · 2021Article
- The Multifaceted Role of CMA in Glioma: Enemy or Ally?International journal of molecular sciences · 2021Review
- Deciphering the Role of CaCancers · 2021Review
- The Expression Patterns ofJournal of clinical medicine · 2020Article
- Article
- LAMP1 is more sensitive than LAMP2 in predicting prognosis of esophageal squamous cell carcinoma.Translational cancer research · 2020Article
- Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung.Oxidative medicine and cellular longevity · 2020Article
- Identifying an Eight-Gene Signature to Optimize Overall Survival Prediction of Esophageal Adenocarcinoma Using Bioinformatics Analysis of ceRNA Network.OncoTargets and therapy · 2020Article
- Acidosis and cancer: from mechanism to neutralization.Cancer metastasis reviews · 2019Review
- Article
- Lamp2 inhibits epithelial-mesenchymal transition by suppressing Snail expression in HCC.Oncotarget · 2018Article
- Differential Expression of TXNIP Isoforms in the Peripheral Leukocytes of Patients with Acute Myocardial Infarction.Disease markers · 2018Article
- Expression and significance of RRBP1 in esophageal carcinoma.Cancer management and research · 2018Article
- Potential biomarkers for the early diagnosis of colorectal adenocarcinoma - transcriptomic analysis of four clinical stages.Cancer biomarkers : section A of Disease markers · 2018Article
- Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease.Medicine · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLAMP2 is one of the major protein components of lysosome. In addition to the expression on the lysosomal membrane, LAMP2 has also been found relocalizing to the cell surface of some highly metastatic tumor cells.
objectiveThe aim of this study was to detect the expression levels of LAMP2 and discuss its roles in esophageal squamous cell carcinoma (ESCC).
methodsSix hundred and ten tissue samples of ESCC were collected to construct tissue microarrays, which were stained by immunohistochemistry.
resultsAfter immunohistochemical staining, 596 patients including 460 men and 136 women were analyzed. The LAMP2 expression levels were significantly different based on degrees of histological differentiation (χ2= 108.906, P< 0.001). The similar results were also observed in TNM stages (χ2= 23.835, P< 0.01). LAMP2 expression levels negatively correlated with degrees of histological differentiation (P< 0.01). Logistic regression analysis showed that the LAMP2 expression levels were correlated with the degrees of histological differentiation (OR=𝑑𝑖𝑓𝑓𝑒𝑟𝑒𝑛𝑡𝑖𝑎𝑡𝑖𝑜𝑛 0.452, P< 0.001) and TNM stages (OR=𝑇𝑁𝑀 1.482, P= 0.42). Besides, Kaplan-Meier survival curves indicated that patients with higher expression of LAMP2 exhibited poor prognosis (P< 0.05).
conclusionsOur results demonstrated that LAMP2 expression levels correlated with tumor histological differentiation and TNM stages. High expression of LAMP2 predicts poor prognosis in patients with ESCC.
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