Evidence map›Paper›PMID 28453430›Full record

ArticleTranscription2017

H2B monoubiquitination: t'ub or not t'ub for inducible enhancers.

Gregory Segala, Didier Picard

Open access · bronzeAbstract read
In one paragraph

Article in Transcription, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. DOT1L complex regulates transcriptional initiation in human erythroleukemic cells.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gregory Segalaa Département de Biologie Cellulaire , Université de Genève , Genève , Switzerland.
Didier Picarda Département de Biologie Cellulaire , Université de Genève , Genève , Switzerland.
University of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we reported the unexpected finding that the monoubiquitination of histone H2B (H2Bub1) regulates inducible enhancers. Here, we propose a conceptual framework to reconcile the apparently discrepant roles of H2Bub1 in transcription initiation and elongation, and we discuss how H2Bub1 could regulate cellular processes linked to non-coding transcription.

Indexed as

Regulatory Sequences, Nucleic AcidAnimalsDNA MethylationEstradiolEstrogen Receptor alphaHistonesHumansMCF-7 CellsNF-kappa BRNARNA Polymerase IITranscription Elongation, GeneticTranscription Initiation, GeneticUbiquitinationEstradiolEstrogen Receptor alphaHistonesNF-kappa BRNARNA Polymerase IIbreast cancerchromatin markchromatin remodelerepigeneticsestrogen receptorH2B ubiquitylationhistone varianttranscription initiation

Identifiers

PMID28453430
PMCPMC5423472
OpenAlexW2586241415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.