ArticleLymphatic research and biology2017
Histamine as an Endothelium-Derived Relaxing Factor in Aged Mesenteric Lymphatic Vessels.
Article in Lymphatic research and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Histamine-Receptor Antagonists Slow 10-km Cycling Performance in Competitive Cyclists.Medicine and science in sports and exercise · 2019Trial
- Inflammatory Signal Persistence in Pain: Lymphatic Regulation and Neuroimmune Integration.Biology · 2026Review
- Edema and lymphatic clearance: molecular mechanisms and ongoing challenges.Clinical science (London, England : 1979) · 2023Review
- In Vitro and In Vivo Characterization of the Transdermal Gel Formulation of Desloratadine for Prevention of Obesity and Metabolic Syndrome.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Effect of the snake venom component crotamine on lymphatic endothelial cell responses and lymph transport.Microcirculation (New York, N.Y. : 1994) · 2023Article
- Lymphatic Clearance and Pump Function.Cold Spring Harbor perspectives in medicine · 2023Review
- Lymphatic Senescence: Current Updates and Perspectives.Biology · 2021Review
- Antihistamines Increase Body Mass Index Percentiles and Z-Scores in Hispanic Children.Children (Basel, Switzerland) · 2020Article
- The Role of Lymphatics in Cholestasis: A Comprehensive Review.Seminars in liver disease · 2020Review
- Characterization of rat tail lymphatic contractility and biomechanics: incorporating nitric oxide-mediated vasoregulation.Journal of the Royal Society, Interface · 2020Article
- Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement.Nutrients · 2020Review
- Emerging Roles of Mast Cells in the Regulation of Lymphatic Immuno-Physiology.Frontiers in immunology · 2020Review
- Pathophysiology of aged lymphatic vessels.Aging · 2019Article
- Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Temporal Dynamics of the Rat Thoracic Duct Contractility in the Presence of Imposed Flow.Lymphatic research and biology · 2017Article
- Aged Lymphatic Vessels and Mast Cells in Perilymphatic Tissues.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundKnowledge of the mechanisms by which aging affects contracting lymphatic vessels remains incomplete; therefore, the functional role of histamine in the reaction of aged lymphatic vessels to increases in flow remains unknown. METHODS AND
resultsWe measured and analyzed parameters of lymphatic contractility in isolated and pressurized rat mesenteric lymphatic vessels (MLVs) obtained from 9- and 24-month Fischer-344 rats under control conditions and after pharmacological blockade of nitric oxide (NO) by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME, 100 μM) or/and blockade of histamine production by α-methyl-DL-histidine dihydrochloride (α-MHD, 10 μM). We also quantitatively compared results of immunohistochemical labeling of the histamine-producing enzyme, histidine decarboxylase (HDC) in adult and aged MLVs. Our data provide the first demonstration of an increased functional role of histamine as an endothelial-derived relaxing factor in aged MLVs, which appears in parallel with the abolished role of NO in the reactions of these lymph vessels to increases in flow. In addition, we found an increased expression of HDC in endothelium of aged MLVs.
conclusionsOur findings provide the basis for better understanding of the processes of aging in lymphatic vessels and for setting new important directions for investigations of the aging-associated disturbances in lymph flow and the immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.