ArticleNature microbiology2017
Variability and host density independence in inductions-based estimates of environmental lysogeny.
Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- The hidden role of rhizospheric viruses in promoting nitrogen fixation in soils.Nature communications · 2026Article
- Article
- Refining Viral Production Estimation.Environmental microbiology reports · 2025Article
- Human gut prophage landscape identifies a prophage-mediated fucosylation mechanism alleviating colitis.Nature communications · 2025Article
- Chromosomal Curing Drives an Arms Race Between Bacterial Transformation and Prophage.Molecular biology and evolution · 2025Article
- Article
- Central carbon metabolism switching in lytic versus temperate coral reef viral communities.bioRxiv : the preprint server for biology · 2025Article
- Article
- Biogeographic patterns and drivers of soil viromes.Nature ecology & evolution · 2024Article
- Seasonal trends in lysogeny in an Appalachian oak-hickory forest soil.Applied and environmental microbiology · 2024Article
- Megataxonomy and global ecology of the virosphere.The ISME journal · 2024Review
- Prophages: an integral but understudied component of the human microbiome.Microbial genomics · 2024Article
- Drivers of microbial food-web structure along productivity gradients.Proceedings. Biological sciences · 2023Article
- Bacteriophages playing nice: Lysogenic bacteriophage replication stable in the human gut microbiota.iScience · 2023Article
- Review
- Recruitment of Mobile Genetic Elements for Diverse Cellular Functions in Prokaryotes.Frontiers in molecular biosciences · 2022Review
- Interactions between bacterial and phage communities in natural environments.Nature reviews. Microbiology · 2022Review
- Unveiling Ecological and Genetic Novelty within Lytic and Lysogenic Viral Communities of Hot Spring Phototrophic Microbial Mats.Microbiology spectrum · 2021Article
- Confocal microscopy reveals alterations of thylakoids in Limnospira fusiformis during prophage induction.Protoplasma · 2021Article
- Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temperate bacterial viruses (phages) may enter a symbiosis with their host cell, forming a unit called a lysogen. Infection and viral replication are disassociated in lysogens until an induction event such as DNA damage occurs, triggering viral-mediated lysis. The lysogen-lytic viral reproduction switch is central to viral ecology, with diverse ecosystem impacts. It has been argued that lysogeny is favoured in phages at low host densities. This paradigm is based on the fraction of chemically inducible cells (FCIC) lysogeny proxy determined using DNA-damaging mitomycin C inductions. Contrary to the established paradigm, a survey of 39 inductions publications found FCIC to be highly variable and pervasively insensitive to bacterial host density at global, within-environment and within-study levels. Attempts to determine the source(s) of variability highlighted the inherent complications in using the FCIC proxy in mixed communities, including dissociation between rates of lysogeny and FCIC values. Ultimately, FCIC studies do not provide robust measures of lysogeny or consistent evidence of either positive or negative host density dependence to the lytic-lysogenic switch. Other metrics are therefore needed to understand the drivers of the lytic-lysogenic decision in viral communities and to test models of the host density-dependent viral lytic-lysogenic switch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.