Evidence map›Paper›PMID 28452956›Full record

ArticleMolecules (Basel, Switzerland)2017

Protective Effect of Caffeic Acid Derivatives on tert-Butyl Hydroperoxide-Induced Oxidative Hepato-Toxicity and Mitochondrial Dysfunction in HepG2 Cells.

Tzung-Hsun Tsai, Chun-Hsien Yu, Yu-Ping Chang, Yu-Ting Lin, Ching-Jang Huang, Yueh-Hsiung Kuo, Po-Jung Tsai

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Tzung-Hsun TsaiDepartment of Dentistry, Keelung Chang-Gung Memorial Hospital, Keelung 204, Taiwan. tts1725@gmail.com.
Chun-Hsien YuDepartment of Pediatrics, Taipei Tzu-Chi Hospital, Buddhist Tzu-Chi Medical Foundation, New Taipei City 231, Taiwan. chryu@mail.tcu.edu.tw.
Yu-Ping ChangDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei 106, Taiwan. elf_elisa@yahoo.com.tw.
Yu-Ting LinDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei 106, Taiwan. linyuting830812@gmail.com.
Ching-Jang HuangInstitute of Microbiology and Biochemistry, and Department of Biochemical Science and Technology, National Taiwan University, Taipei 106, Taiwan. cjjhuang@ntu.edu.tw.
Yueh-Hsiung KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan. kuoyh@mail.cmu.edu.tw.
Po-Jung TsaiDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei 106, Taiwan. pjtsai@ntnu.edu.tw.
National Taiwan Normal University · TWAsia University · TWKeelung Chang Gung Memorial Hospital · TWNational Taiwan University · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress results in structural and functional abnormalities in the liver and is thought to be a crucial factor in liver diseases. The aim of this study was to investigate the cytoprotective and antioxidant effects of caffeic acid (CA) derivatives on

Indexed as

AntioxidantsCaffeic AcidsCell SurvivalChemical and Drug Induced Liver InjuryDrug Evaluation, PreclinicalGlutathioneHep G2 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitLipid PeroxidationMitochondria, LiverNF-E2-Related Factor 2Oxidative Stresstert-ButylhydroperoxideAntioxidantsCaffeic AcidsGlutathioneHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitNFE2L2 protein, humanNF-E2-Related Factor 2tert-Butylhydroperoxideantioxidantcaffeic acid derivativesliver protectiontert-butyl hydroperoxide

Identifiers

PMID28452956
PMCPMC6154103
OpenAlexW2609036588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.