Evidence map›Paper›PMID 28452714›Full record

ArticleeLife2017

The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status.

Dongming Li, Ana Marie S Palanca, So Youn Won, Lei Gao, Ying Feng, Ajay A Vashisht, Li Liu, Yuanyuan Zhao, Xigang Liu, Xiuyun Wu and 11 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Dongming LiDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Ana Marie S PalancaPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, United States.ORCID 0000-0003-4527-7604
So Youn WonDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Lei GaoDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Ying FengDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Ajay A VashishtDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, United States.
Li LiuDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Yuanyuan ZhaoDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Xigang LiuDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Xiuyun WuDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Shaofang LiDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Brandon LeDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Yun Ju KimDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Guodong YangDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Shengben LiDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.
Jinyuan LiuLaboratory of Molecular Biology and Protein Science, Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China.
James A WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, United States.
Hongwei GuoState Key Laboratory of Protein and Plant Gene research, College of Life Sciences, Peking University, Beijing, China.
Beixin MoCollege of Life Sciences and Oceanography, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen University, Shenzhen, China.
Xuemei ChenDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, United States.ORCID 0000-0002-5209-1157
Julie A LawPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, United States.ORCID 0000-0001-7472-7753
University of California, Riverside · USSalk Institute for Biological Studies · USPeking University · CNShenzhen University · CNUniversity of California, Los Angeles · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8M
Regulation of APETALA2 in flower development in ArabidopsisR01GM061146 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI CHEN, MENG · 2000 to 2022
$6.5M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Establishment and Modulation of DNA Methylation Patterns in ArabidopsisR01GM112966 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI LAW, JULIE ANN · 2015 to 2024
$3.5M
NCI NIH HHS P30 CA014195NIGMS NIH HHS R01 GM061146NIGMS NIH HHS R01 GM089778NIGMS NIH HHS R01 GM112966
6 · The paper itself

Abstract

DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene expression. Here we identified a METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex in

Indexed as

ArabidopsisDNA MethylationGene Expression Regulation, PlantDNA-Binding ProteinsGenes, ReporterLuciferasesPlant ProteinsTransgenesDNA-Binding ProteinsLuciferasesPlant ProteinsA. thalianachromosomesDNA methylationgenesHSP20Methyl-CpG-Binding Domain (MBD)plant biologyRNA-directed DNA methylation (RdDM)transcriptional gene silencingα-crystallin domain (ACD)

Identifiers

PMID28452714
PMCPMC5462541
OpenAlexW2608485885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.