ArticleJournal of psychiatry & neuroscience : JPN2017
Decreased uncinate fasciculus tract integrity in male and female patients with PTSD: a diffusion tensor imaging study.
Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.Molecular psychiatry · 2021Pooled it
- Structural white matter changes in adults and children with posttraumatic stress disorder: A systematic review and meta-analysis.NeuroImage. Clinical · 2018Pooled it
- Long term structural and functional neural changes following a single infusion of Ketamine in PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Brain structure changes induced by attention bias modification training.Biological psychology · 2019Trial
- Transdiagnostic neural correlates of post-traumatic stress disorder and mild traumatic brain injury.Brain communications · 2026Article
- Childhood Adversity Is Associated With Longitudinal White Matter Changes After Adulthood Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- The Impact of Early Life Experiences on Stress Neurobiology and the Development of Anxiety.Current topics in behavioral neurosciences · 2025Review
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm.Neuroimage. Reports · 2024Article
- Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure.European heart journal · 2024Article
- Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions.Journal of Zhejiang University. Science. B · 2024Article
- Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm.medRxiv : the preprint server for health sciences · 2023Article
- Micro-structural white matter abnormalities in new daily persistent headache: a DTI study using TBSS analysis.The journal of headache and pain · 2023Article
- White matter microstructure predicts individual differences in infant fear (But not anger and sadness).Developmental science · 2023Article
- Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury.Journal of clinical medicine · 2023Article
- White matter connectivity in resilience in a general population sample of 12,516 individuals.Neuroscience applied · 2023Article
- Characterizing White Matter Changes along Fibers in Treatment-Naive Pediatric Posttraumatic Stress Disorder.Depression and anxiety · 2023Article
- Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans.Journal of Alzheimer's disease : JAD · 2023Article
- Neurobiological Features of Posttraumatic Stress Disorder (PTSD) and Their Role in Understanding Adaptive Behavior and Stress Resilience.International journal of environmental research and public health · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPosttraumatic stress disorder (PTSD) is a disabling psychiatric disorder that has been associated with lower white matter integrity of tracts connecting the prefrontal cortex with limbic regions. However, previous diffusion tensor imaging (DTI) findings have been inconsistent, showing high variability in the exact location and direction of effects.
methodsWe performed probabilistic tractography of the bilateral uncinate fasciculus, cingulum and superior longitudinal fasciculus (both temporal and parietal projections) in male and female police officers with and without PTSD.
resultsWe included 38 (21 men) police officers with and 39 (20 men) without PTSD in our analyses. Compared with trauma-exposed controls, patients with PTSD showed significantly higher mean diffusivity of the right uncinate fasciculus, the major white matter tract connecting the amygdala to the prefrontal cortex ( LIMITATIONS: Our specific sample of trauma-exposed police officers limits the generalizability of our findings to other PTSD patient groups (e.g., civilian trauma).
conclusionPatients with PTSD showed diminished structural connectivity between the amygdala and vmPFC, which was correlated with higher anxiety symptoms and increased functional activity of these brain regions. Our findings provide additional evidence for the prevailing neurocircuitry model of PTSD, postulating that ineffective communication between the amygdala and vmPFC underlies decreased top-down control over fear responses.
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