ArticleAdipocyte2017
Habitual physical activity protects against lipopolysaccharide-induced inflammation in mouse adipose tissue.
Article in Adipocyte, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Protective effect of exercise on animals with sepsis: a systematic review of the existing literature.BMC infectious diseases · 2025Pooled it
- The Effects of 10-Week Strength Training in the Winter on Brown-like Adipose Tissue Vascular Density.International journal of environmental research and public health · 2022Trial
- Beneficial Effects of Linseed Supplementation on Gut Mucosa-Associated Microbiota in a Physically Active Mouse Model of Crohn's Disease.International journal of molecular sciences · 2022Article
- Healthy versus Unhealthy Adipose Tissue Expansion: the Role of Exercise.Journal of obesity & metabolic syndrome · 2022Review
- Exercise reduced the formation of new adipocytes in the adipose tissue of mice in vivo.PloS one · 2021Article
- Modulation of TRIB3 and Macrophage Phenotype to Attenuate Insulin Resistance After Downhill Running in Mice.Frontiers in physiology · 2021Article
- Looking on the "brite" side exercise-induced browning of white adipose tissue.Pflugers Archiv : European journal of physiology · 2019Review
- Article
- Effects of exercise on brown and beige adipocytes.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis.The Journal of physiology · 2018Article
- Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats.Adipocyte · 2018Article
- Subcutaneous inguinal white adipose tissue is responsive to, but dispensable for, the metabolic health benefits of exercise.American journal of physiology. Endocrinology and metabolism · 2018Article
- Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21.The Journal of endocrinology · 2017Article
- Cycling our way to fit fat.Physiological reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a systemic inflammatory response to infection, with no preventative strategies. In this study, we identify a role for habitual physical activity in the prevention of adipose tissue inflammation induced by a model of sepsis, lipopolysaccharide (LPS). Male C57BL/6J mice (8 weeks old) were housed with access to voluntary wheel running (VWR) or sedentary (SED) for 10 weeks. Mice were then injected with LPS (2 mg/kg) or saline (SAL), and tissues were removed 6 hours post-injection. VWR attenuated body, epididymal adipose tissue (eWAT), and subcutaneous inguinal adipose tissue (iWAT) mass gain, improved glucose tolerance, increased markers of mitochondrial biogenesis in iWAT and eWAT, and increased UCP-1 protein content in iWAT. In iWAT, VWR attenuated the LPS induced increase in mRNA expression of TNF-α, MCP-1, and follistatin, along with phosphorylation of STAT3. In addition, VWR had a main effect for reducing iWAT mRNA expression of IL-1β, IL-6, and SOCS3. In eWAT, VWR had a main effect for reducing mRNA expression of IL-1β, MCP-1, IL-6, and follistatin. Further, VWR increased SOCS3 mRNA expression and phosphorylation of STAT3 in SAL mice, thus the relative change in response to LPS for these markers was attenuated. The protective effect of prior physical activity occurred in conjunction with increases in the protein content of a component of the LPS binding complex, MyD88. Overall, the results from this study demonstrate that habitual physical activity can attenuate the LPS induced inflammatory response in adipose tissue and this occurs to a greater extent in iWAT compare with eWAT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.