SynthesisScientific reports2017
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
Erratum issuedAbstract readMeta-Analysis
In one paragraph
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 77 papers, 9 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 9 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Genome-Wide Association Study for eGFR in a Taiwanese Population.Clinical journal of the American Society of Nephrology : CJASN · 2022Pooled it
- First genome-wide association study investigating blood pressure and renal traits in domestic cats.Scientific reports · 2022Pooled it
- Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.Nature communications · 2021Pooled it
- Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.Science translational medicine · 2020Pooled it
- Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.Nature communications · 2020Pooled it
- A catalog of genetic loci associated with kidney function from analyses of a million individuals.Nature genetics · 2019Pooled it
- Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.Nature communications · 2019Pooled it
- Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.Nature communications · 2019Pooled it
- Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.Journal of the American Society of Nephrology : JASN · 2018Pooled it
- Kidney function decline and kidney stone risk: cohort and Mendelian randomization analyses.Renal failure · 2026Article
- S-acylation and membrane localization of the small GTPase ARL15 are mediated by the Golgi S-acyltransferases ZDHHC7 and ZDHHC3.The Journal of biological chemistry · 2026Article
- African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels.Genome medicine · 2026Article
- Genome-wide association analysis of cystatin c and creatinine kidney function in Chinese women.BMC medical genomics · 2024Article
- Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease.NPJ systems biology and applications · 2024Article
- Novel Aspects of Immunogenetics and Post-Transplant Events in Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Replacing a kidney biopsy by exome sequencing in undetermined kidney diseases-not yet ready for prime time!Clinical kidney journal · 2024Article
- Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation, pleiotropic analysis, and Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Genetic association and transferability for urinary albumin-creatinine ratio as a marker of kidney disease in four Sub-Saharan African populations and non-continental individuals of African ancestry.Frontiers in genetics · 2024Article
- Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15.eLife · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedCorrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.2017 · de Borst, Martin H [corrected to de Borst, Martin]
Authors and funding
126 authors.
Mathias GorskiDepartment of Genetic Epidemiology, University Regensburg, Regensburg, Germany.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, P.O. box 30.001, 9700 RB Groningen, The Netherlands.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Walther-Rathenau-Str. 48, 17475 Greifswald, Germany.
Audrey Y ChuNHLBI's Framingham Heart Study, Framingham, MA 01702, USA.
Man LiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615N Wolfe St, Baltimore, MD, 21205, USA.
Vladan MijatovicDepartment of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, P.O. box 30.001, 9700 RB Groningen, The Netherlands.
Massimiliano CoccaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132, Milano, Italy.
Daniel TaliunCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.
Felicia GomezDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63108, USA.
Yong LiDivision of Genetic Epidemiology, Medical Center and Faculty of Medicine - University of Freiburg, Freiburg, Germany.
Bamidele TayoLoyola University Chicago, 2160 South First Avenue, Bldg 105, Maywood, IL 60153, USA.
Adrienne TinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615N Wolfe St, Baltimore, MD, 21205, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63108, USA.
Thor AspelundIcelandic Heart Association, Kopavogur, Iceland.
John AttiaSchool of Medicine and Public Health, University of Newcastle, Australia.
Reiner BiffarClinic for Prosthodontic Dentistry, Gerostomatology and Material Science, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
Murielle BochudInstitute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Route de la Corniche 10, 1010, Lausanne, Switzerland.
Eric BoerwinkleUniversity of Texas Health Science Center at Houston, USA.
Ingrid BoreckiRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, USA.
Ming-Huei ChenNHLBI's Framingham Heart Study, Framingham, MA 01702, USA.
Vincent ChourakiInserm U1167, Lille University, Institut Pasteur de Lille, Lille, France.
Marina CiulloInstitute of Genetics and Biophysics, "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, 80131 Napoli, Italy.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615N Wolfe St, Baltimore, MD, 21205, USA.
Marilyn C CornelisDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1400 Chicago, IL 60611, USA.
Gary C CurhanRenal Division, Brigham and Women's Hospital, USA.
Adamo Pio d'AdamoClinical Department of Medical, Surgical and Health Science, University of Trieste, Italy.
Abbas DehghanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Laura DenglerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Jingzhong DingWake Forest School of Medicine, USA.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Karlhans EndlichInstitute of Anatomy and Cell Biology, University Medicine Greifswald, Friedrich-Loeffler-Str. 23c, 17475 Greifswald, Germany.
Stefan EnrothDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, SE-75108 Uppsala, Sweden.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Paolo GaspariniDepartment of Medical Sciences, Chirurgical and Health Department, University of Trieste, Trieste, Italy.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Giorgia GirottoDepartment of Medical Sciences, Chirurgical and Health Department, University of Trieste, Trieste, Italy.
Omri GottesmanThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Ulf GyllenstenDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, SE-75108 Uppsala, Sweden.
Stephen J HancockSchool of Medicine and Public Health, University of Newcastle, Australia.
Tamara B HarrisIntramural Research Program, Laboratory of Epidemiology and Population Studies, National Institute on Aging, USA.
Catherine HelmerINSERM, Centre INSERM Research Center U1219, Bordeaux, France.
Simon HöllererDepartment of Genetic Epidemiology, University Regensburg, Regensburg, Germany.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Elizabeth G HollidayPublic Health Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15a, 17475 Greifswald, Germany.
Frank B HuDepartment of Nutrition, Harvard School of Public Health and Channing Division of Network Medicine, Brigham and Women's Hospital, USA.
Cornelia HuthInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Nina Hutri-KähönenDepartment of Pediatrics, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland.
Shih-Jen HwangNHLBI's Framingham Heart Study, Framingham, MA 01702, USA.
Medea ImbodenUnit Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Åsa JohanssonDepartment of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, SE-75108 Uppsala, Sweden.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
Wolfgang KönigDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Holly KramerLoyola University Chicago, 2160 South First Avenue, Bldg 105, Maywood, IL 60153, USA.
Bernhard K KrämerUniversity Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg, Theodor Kutzer Ufer 1-3, 68167 Mannheim, Germany.
Ashish KumarUnit Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Zoltan KutalikInstitute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Route de la Corniche 10, 1010, Lausanne, Switzerland.
Jean-Charles LambertInserm U1167, Lille University, Institut Pasteur de Lille, Lille, France.
Lenore J LaunerIntramural Research Program, Laboratory of Epidemiology and Population Studies, National Institute on Aging, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Martin de BorstUniversity Medical Center Groningen, University of Groningen, The Netherlands.
Gerjan NavisUniversity Medical Center Groningen, University of Groningen, The Netherlands.
Morris SwertzUniversity Medical Center Groningen, University of Groningen, The Netherlands.
Yongmei LiuWake Forest School of Medicine, USA.
Kurt LohmanWake Forest School of Medicine, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, USA.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Mark A McEvoySchool of Medicine and Public Health, University of Newcastle, Australia.
Christa MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Marie MetzgerInserm U1018, University Paris-Sud, UVSQ, University Paris-Saclay, Villejuif, France.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu, Estonia.
Paul MitchellCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney C24, NSW, 2145, Australia.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine-University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, P.O. box 30.001, 9700 RB, Groningen, The Netherlands.
Matthias OldenDepartment of Genetic Epidemiology, University Regensburg, Regensburg, Germany.
Brenda Wjh PenninxDepartment of Psychiatry, Vrije Universiteit, VU University Medical Center, NESDA, A.J. Ernststraat 1187, 1081HL Amsterdam, The Netherlands.
Giorgio PistisDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132, Milano, Italy.
Peter P PramstallerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.
Nicole Probst-HenschUnit Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
Rainer RettigInstitute of Physiology, University Medicine Greifswald, 17475 Greifswald, Germany.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02215, USA.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Antonietta RobinoInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Sylvia E RosasJoslin Diabetes Center. Harvard Medical School, Boston, MA, USA.
Douglas RuderferThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, USA.
Daniela RuggieroInstitute of Genetics and Biophysics, "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, 80131 Napoli, Italy.
Yasaman SabaInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria.
Cinzia SalaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132, Milano, Italy.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Australia.
Sanaz SedaghatDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Rossella SoriceInstitute of Genetics and Biophysics, "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, 80131 Napoli, Italy.
Benedicte StengelInserm U1018, University Paris-Sud, UVSQ, University Paris-Saclay, Villejuif, France.
Sylvia StrackeClinic for Internal Medicine A, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Daniela TonioloDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132, Milano, Italy.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Sheila UliviInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Jorma S ViikariDivision of Medicine, Turku University Hospital, Turku 20521, Finland.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15a, 17475 Greifswald, Germany.
Peter VollenweiderDepartment of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Walther-Rathenau-Str. 48, 17475 Greifswald, Germany.
Dragana VuckovicDepartment of Medical Sciences, Chirurgical and Health Department, University of Trieste, Trieste, Italy.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Jie Jin WangCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney C24, NSW, 2145, Australia.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02215, USA.
Gerard TrompWeis Center for Research, Geisinger Clinic, Danville, Pennsylvania, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, P.O. box 30.001, 9700 RB Groningen, The Netherlands.
Iris M HeidDepartment of Genetic Epidemiology, University Regensburg, Regensburg, Germany.
Caroline S FoxNHLBI's Framingham Heart Study, Framingham, MA 01702, USA.
Anna KöttgenDivision of Genetic Epidemiology, Medical Center and Faculty of Medicine - University of Freiburg, Freiburg, Germany.
Cristian PattaroCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Christian FuchsbergerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Bolzano, Italy.
Funding
The Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0MBrain aging and cardiovascular risk factors and diseaseZIAAG007480 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2011 to 2025
$2.7MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MGenetic analysis of AGES-Reykjavik Study and the Health ABCZIAAG006000 · NIA · NATIONAL INSTITUTE ON AGING · PI HARRIS, TAMARA · 2009 to 2017
$1.3MRisk of Chronic Kidney Disease Associated with GSTM1 DeletionsR21DK112087 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TIN, ADRIENNE · 2016 to 2017
$367kNCI NIH HHS UM1 CA182913NIDDK NIH HHS R21 DK112087NIH HHS S10 OD018522
Abstract
HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10
Indexed as
Genetic LociComputational BiologyGene FrequencyGenome, HumanGenome-Wide Association StudyGenotyping TechniquesHumansKidneyPolymorphism, Single Nucleotide
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