ArticleNature communications2017
Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 176 citations in OpenAlex.
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- Comparative genomic analyses shed light on the introduction routes of rice-pathogenic Burkholderia gladioli strains into Bangladesh.BMC genomics · 2026Article
- Origin and function of beneficial bacterial symbioses in insects.Nature reviews. Microbiology · 2025Review
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- Organ structure and bacterial microbiogeography in a reproductive organ of the Hawaiian bobtail squid reveal dimensions of a defensive symbiosis.Applied and environmental microbiology · 2025Article
- Defensive Symbiont Genotype Distributions Are Linked to Parasitoid Attack Networks.Ecology letters · 2025Article
- Microbiome composition and turnover in the face of complex lifecycles and bottlenecks: insights through the study of dung beetles.Applied and environmental microbiology · 2025Article
- Insect‒microbe symbiosis-based strategies offer a new avenue for the management of insect pests and their transmitted pathogens.Crop health · 2024Review
- Adaptation During the Shift from Entomopathogen to Endosymbiont Is Accompanied by Gene Loss and Intensified Selection.Genome biology and evolution · 2024Article
- Prophylactic phage biocontrol preventsApplied and environmental microbiology · 2024Article
- Repeated horizontal acquisition of lagriamide-producing symbionts in Lagriinae beetles.bioRxiv : the preprint server for biology · 2024Article
- The role of animal hosts in shaping gut microbiome variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
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- Repeated horizontal acquisition of lagriamide-producing symbionts in Lagriinae beetles.The ISME journal · 2024Article
- The Eurasian spruce bark beetleFrontiers in microbiology · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogenic and mutualistic bacteria associated with eukaryotic hosts often lack distinctive genomic features, suggesting regular transitions between these lifestyles. Here we present evidence supporting a dynamic transition from plant pathogenicity to insect-defensive mutualism in symbiotic Burkholderia gladioli bacteria. In a group of herbivorous beetles, these symbionts protect the vulnerable egg stage against detrimental microbes. The production of a blend of antibiotics by B. gladioli, including toxoflavin, caryoynencin and two new antimicrobial compounds, the macrolide lagriene and the isothiocyanate sinapigladioside, likely mediate this defensive role. In addition to vertical transmission, these insect symbionts can be exchanged via the host plant and retain the ability to initiate systemic plant infection at the expense of the plant's fitness. Our findings provide a paradigm for the transition between pathogenic and mutualistic lifestyles and shed light on the evolution and chemical ecology of this defensive mutualism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.