ArticleScientific reports2017
WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Effects of oxycodone on tonic levels and phasic release of serotonin in the rat nucleus accumbens core.Bioelectrochemistry (Amsterdam, Netherlands) · 2026Article
- From trade-offs to translation: An interdisciplinary roadmap for neurotechnology.Science advances · 2026Review
- Multiplexer-based system development for multichannel neurochemical sensing.Biomedical engineering letters · 2026Article
- Boron-Doped Nano-Crystalline Coated Carbon Fibers for Phasic Dopamine Sensing.Advanced healthcare materials · 2026Article
- Machine Learning for Neurotransmitter Monitoring by Fast Voltammetry: Current and Future Prospects.ACS chemical neuroscience · 2026Review
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing.Biosensors · 2025Review
- Article
- Improved longevity andFrontiers in bioengineering and biotechnology · 2025Article
- Biochemical Sensors for Personalized Therapy in Parkinson's Disease: Where We Stand.Journal of clinical medicine · 2024Review
- Ventral tegmental area deep brain stimulation reverses ethanol-induced dopamine increase in the rat nucleus accumbens.Biomedical engineering letters · 2024Article
- Harnessing the sensing and stimulation function of deep brain-machine interfaces: a new dawn for overcoming substance use disorders.Translational psychiatry · 2024Review
- Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry.ACS omega · 2024Article
- Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission.Brain : a journal of neurology · 2023Article
- High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens.Frontiers in neuroscience · 2023Article
- Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation.Frontiers in pharmacology · 2023Article
- Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens.Journal of neurophysiology · 2022Article
- Biomarkers for Deep Brain Stimulation in Animal Models of Depression.Neuromodulation : journal of the International Neuromodulation Society · 2022Review
- Wearable Electrochemical Sensors in Parkinson's Disease.Sensors (Basel, Switzerland) · 2022Article
- Software for near-real-time voltammetric tracking of tonic neurotransmitter levelsFrontiers in neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry. Here, we present a research platform, WINCS Harmoni, which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. In addition, WINCS Harmoni can provide real-time neurochemical feedback for closed-loop control of neurochemical levels via its synchronized stimulation and neurochemical sensing capabilities. We demonstrate these and other key features of this platform in non-human primate, swine, and rodent models of deep brain stimulation (DBS). Ultimately, systems like the one described here will improve our understanding of the dynamics of brain physiology in the context of neurologic disease and therapeutic interventions, which may lead to the development of precision medicine and personalized therapies for optimal therapeutic efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.