ArticleBiomedical materials (Bristol, England)2017
Performance of laser sintered Ti-6Al-4V implants with bone-inspired porosity and micro/nanoscale surface roughness in the rabbit femur.
Article in Biomedical materials (Bristol, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Nanoscale Morphologies on the Surface of 3D-Printed Titanium Implants for Improved Osseointegration: A Systematic Review of the Literature.International journal of nanomedicine · 2023Pooled it
- Surface modifications and coatings to improve osseointegration and antimicrobial activity on titanium surfaces: A statistical review over the last decade.Journal of orthopaedics · 2025Review
- Radial Head Prosthesis with Interconnected Porosity Showing Low Bone Resorption Around the Stem.Journal of clinical medicine · 2025Article
- Effect of Ti6Al4V Alloy Surface and Porosity on Bone Osseointegration: In Vivo Pilot Study in Rabbits.Materials (Basel, Switzerland) · 2025Article
- Corrosion and Biocompatibility Studies of Bioceramic Alumina Coatings on Aluminum Alloy 6082.ACS applied materials & interfaces · 2025Article
- Article
- Development of Bioactive Scaffolds for Orthopedic Applications by Designing Additively Manufactured Titanium Porous Structures: A Critical Review.Biomimetics (Basel, Switzerland) · 2023Review
- Serial Cultivation of an MSC-Like Cell Line with Enzyme-Free Passaging Using a Microporous Titanium Scaffold.Materials (Basel, Switzerland) · 2023Article
- Implant-bone-interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo.Bioengineering & translational medicine · 2022Review
- Lipidome profiling with Raman microspectroscopy identifies macrophage response to surface topographies of implant materials.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Investigation of Patient-Specific Maxillofacial Implant Prototype Development by Metal Fused Filament Fabrication (MFDentistry journal · 2021Article
- Osseointegration of a novel 3D porous Ti-6Al-4V implant material - Histomorphometric analysis in rabbits.Histology and histopathology · 2021Article
- Sequential osseointegration from osseohealing to osseoremodeling - Histomorphological comparison of novel 3D porous and solid Ti-6Al-4V titanium implants.Histology and histopathology · 2021Article
- Osseointegration of porous titanium and tantalum implants in ovariectomized rabbits: A biomechanical study.World journal of orthopedics · 2021Article
- In vivo performance of AlJournal of orthopaedic surgery and research · 2021Article
- Hot isostatic pressure treatment of 3D printed Ti6Al4V alters surface modifications and cellular response.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Scaffolds and coatings for bone regeneration.Journal of materials science. Materials in medicine · 2020Review
- In vivo osseointegration of a randomized trabecular titanium structure obtained by an additive manufacturing technique.Journal of materials science. Materials in medicine · 2020Article
- The effect of surface topography and porosity on the tensile fatigue of 3D printed Ti-6Al-4V fabricated by selective laser melting.Materials science & engineering. C, Materials for biological applications · 2019Article
- Osseointegration of a 3D Printed Stemmed Titanium Dental Implant: A Pilot Study.International journal of dentistry · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Long term success of bone-interfacing implants remains a challenge in compromised patients and in areas of low bone quality. While surface roughness at the micro/nanoscale can promote osteogenesis, macro-scale porosity is important for promoting mechanical stability of the implant over time. Currently, machining techniques permit pores to be placed throughout the implant, but the pores are generally uniform in dimension. The advent of laser sintering provides a way to design and manufacture implants with specific porosity and variable dimensions at high resolution. This approach enables production of metal implants that mimic complex geometries found in biology. In this study, we used a rabbit femur model to compare osseointegration of laser sintered solid and porous implants. Ti-6Al-4V implants were laser sintered in a clinically relevant size and shape. One set of implants had a novel porosity based on human trabecular bone; both sets had grit-blasted/acid-etched surfaces. After characterization, implants were inserted transaxially into rabbit femora; mechanical testing, micro-computed tomography (microCT) and histomorphometry were conducted 10 weeks post-operatively. There were no differences in pull-out strength or bone-to-implant contact. However, both microCT and histomorphometry showed significantly higher new bone volume for porous compared to solid implants. Bone growth was observed into porous implant pores, especially near apical portions of the implant interfacing with cortical bone. These results show that laser sintered Ti-6Al-4V implants with micro/nanoscale surface roughness and trabecular bone-inspired porosity promote bone growth and may be used as a superior alternative to solid implants for bone-interfacing implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.