Evidence map›Paper›PMID 28452287›Full record

ArticleJournal of biological rhythms2017

Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression.

Amelia K Luciano, Jeans M Santana, Heino Velazquez, William C Sessa

Open access · bronzeAbstract read
In one paragraph

Article in Journal of biological rhythms, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amelia K LucianoDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut.
Jeans M SantanaDepartment of Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut.
Heino VelazquezDepartment of Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut.
William C SessaDepartment of Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut.
Yale University · US

Funding

Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8M
PHOSPHORYLATION AND ENDOTHELIAL NITRIC OXIDE PRODUCTIONR01HL064793 · NHLBI · YALE UNIVERSITY · PI SESSA, WILLIAM C · 2000 to 2016
$6.3M
INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32GM007324 · NIGMS · YALE UNIVERSITY · PI BENNETT, ANTON M · 1987 to 2022
$6.2M
Endothelial NOS by protein to protein interactionsR37HL061371 · NHLBI · YALE UNIVERSITY · PI SESSA, WILLIAM C · 2009 to 2017
$4.1M
Endothelial NOS by Protein-Protein IntractionsR01HL061371 · NHLBI · YALE UNIVERSITY · PI SESSA, WILLIAM C · 1999 to 2008
$3.6M
NHLBI NIH HHS R01 HL061371NHLBI NIH HHS R01 HL064793NHLBI NIH HHS R37 HL061371NIDDK NIH HHS P30 DK079310NIGMS NIH HHS T32 GM007324
6 · The paper itself

Abstract

The AKT signaling pathway is important for circadian rhythms in mammals and flies ( Drosophila). However, AKT signaling in mammals is more complicated since there are 3 isoforms of AKT, each performing slightly different functions. Here we study the most ubiquitous AKT isoform, Akt1, and its role at the organismal level in the central and vascular peripheral clocks. Akt1

Indexed as

Gene Expression RegulationAnimalsAortaCircadian RhythmEndothelial CellsLiverMiceMice, KnockoutProtein IsoformsProto-Oncogene Proteins c-aktSignal TransductionAkt1 protein, mouseProtein IsoformsProto-Oncogene Proteins c-aktAktamplitudeaortacircadian rhythmsgene expression

Identifiers

PMID28452287
PMCPMC5703205
OpenAlexW2608517497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.