ArticleThe European journal of neuroscience2017
Myosin II activity is required for structural plasticity at the axon initial segment.
Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Abl kinase activation promotes axon initial segment disassembly and protein sorting defects in Alzheimer's disease.BMC biology · 2026Article
- Characterisation of the axon initial segment and intrinsic excitability in the sub-acute phase post-ischaemic stroke.Brain communications · 2026Article
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- Unveiling the cell biology of hippocampal neurons with dendritic axon origin.The Journal of cell biology · 2025Article
- Article
- Actin polymerization and longitudinal actin fibers in axon initial segment plasticity.Frontiers in molecular neuroscience · 2024Article
- Sodium channel endocytosis drives axon initial segment plasticity.Science advances · 2023Article
- The role of the membrane-associated periodic skeleton in axons.Cellular and molecular life sciences : CMLS · 2021Review
- Pharmacological Modulation of Neurite Outgrowth in Human Neural Progenitor Cells by Inhibiting Non-muscle Myosin II.Frontiers in cell and developmental biology · 2021Article
- Trafficking mechanisms underlying NaChannels (Austin, Tex.) · 2020Review
- Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines.Cells · 2020Review
- Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment.Cells · 2020Review
- Review
- Effect of allosteric inhibition of non-muscle myosin 2 on its intracellular diffusion.Scientific reports · 2020Article
- Cytoskeletal organization of axons in vertebrates and invertebrates.The Journal of cell biology · 2020Article
- Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment.iScience · 2020Article
- Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability.The Journal of cell biology · 2020Article
- Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins.Scientific reports · 2019Article
- Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development.Frontiers in cellular neuroscience · 2019Article
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4 authors at 1 institution in 2 countries.
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Abstract
In neurons, axons possess a molecularly defined and highly organised proximal region - the axon initial segment (AIS) - that is a key regulator of both electrical excitability and cellular polarity. Despite existing as a large, dense structure with specialised cytoskeletal architecture, the AIS is surprisingly plastic, with sustained alterations in neuronal activity bringing about significant alterations to its position, length or molecular composition. However, although the upstream activity-dependent signalling pathways that lead to such plasticity have begun to be elucidated, the downstream mechanisms that produce structural changes at the AIS are completely unknown. Here, we use dissociated cultures of rat hippocampus to show that two forms of AIS plasticity in dentate granule cells - long-term relocation, and more rapid shortening - are completely blocked by treatment with blebbistatin, a potent and selective myosin II ATPase inhibitor. These data establish a link between myosin II and AIS function, and suggest that myosin II's primary role at the structure may be to effect activity-dependent morphological alterations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.