ArticleBritish journal of pharmacology2017
Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Dual Blockade of PI3K and EGFR Pathways by Flavonoids fromFoods (Basel, Switzerland) · 2025Article
- Prunin: An Emerging Anticancer Flavonoid.International journal of molecular sciences · 2025Review
- Extraction, purification and antioxidant activity of flavonoids fromFrontiers in bioengineering and biotechnology · 2025Article
- A Review on Picrosides Targeting NFκB and its Proteins for Treatment of Breast Cancer.Cell biochemistry and biophysics · 2024Review
- Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes.Journal of molecular endocrinology · 2024Article
- Three sesquiterpene lactones suppress lung adenocarcinoma by blocking TMEM16A-mediated CaThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- New flavone-based arylamides as potentialJournal of Taibah University Medical Sciences · 2023Article
- Treatment of Gastrointestinal Disorders-Plants and Potential Mechanisms of Action of Their Constituents.Molecules (Basel, Switzerland) · 2022Review
- Anticancer Activity of Natural and Synthetic Chalcones.International journal of molecular sciences · 2021Review
- Emerging Modulators of TMEM16A and Their Therapeutic Potential.The Journal of membrane biology · 2021Review
- The CaActa pharmaceutica Sinica. B · 2021Review
- Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis.Journal of experimental pharmacology · 2021Review
- The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin.Frontiers in pharmacology · 2021Article
- Benzophenanthridine alkaloids suppress lung adenocarcinoma by blocking TMEM16A CaPflugers Archiv : European journal of physiology · 2020Article
- The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A.Biophysical journal · 2020Article
- The multifaceted role of TMEM16A in cancer.Cell calcium · 2019Review
- Modulatory Effect of Selected Dietary Phytochemicals on Delayed Rectifier KThe Journal of membrane biology · 2019Article
- Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation.Pflugers Archiv : European journal of physiology · 2018Article
- [Diltiazem inhibits proliferation and motility of hepatocellular cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects.British journal of pharmacology · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeNatural flavonoids are ubiquitous in dietary plants and vegetables and have been proposed to have antiviral, antioxidant, cardiovascular protective and anticancer effects. Transmembrane member 16A (TMEM16A)-encoded Ca EXPERIMENTAL APPROACH: A whole-cell patch technique was used to record the currents. The BrdU assay and transwell technique were used to investigate cell proliferation and migration. KEY
resultsAt a concentration of 100 μM, 10 of 20 compounds caused significant (>50%) inhibition of TMEM16A currents. The four most potent compounds - luteolin, galangin, quercetin and fisetin - had IC CONCLUSIONS AND IMPLICATIONS: This study demonstrates that flavonoids inhibit TMEM16A currents and suggests that flavonoids could have anticancer effects via this mechanism.
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