Evidence map›Paper›PMID 28452004›Full record

ArticleIn vitro cellular & developmental biology. Animal2017

In vitro anticancer properties of selected Eucalyptus species.

Deep Jyoti Bhuyan, Jennette Sakoff, Danielle R Bond, Melanie Predebon, Quan V Vuong, Anita C Chalmers, Ian A van Altena, Michael C Bowyer, Christopher J Scarlett

Abstract read
PubMed Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. The Odyssey of Bioactive Compounds in Avocado (Antioxidants (Basel, Switzerland) · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Deep Jyoti BhuyanPancreatic Cancer Research Group, School of Environmental and Life Sciences, University of Newcastle, 10 Chittaway Rd, Ourimbah, NSW, 2258, Australia. deepjyoti.bhuyan@uon.edu.au.ORCID http://orcid.org/0000-0002-9736-0197
Jennette SakoffDepartment of Medical Oncology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia.
Danielle R BondPancreatic Cancer Research Group, School of Environmental and Life Sciences, University of Newcastle, 10 Chittaway Rd, Ourimbah, NSW, 2258, Australia.
Melanie PredebonPancreatic Cancer Research Group, School of Environmental and Life Sciences, University of Newcastle, 10 Chittaway Rd, Ourimbah, NSW, 2258, Australia.
Quan V VuongPancreatic Cancer Research Group, School of Environmental and Life Sciences, University of Newcastle, 10 Chittaway Rd, Ourimbah, NSW, 2258, Australia.
Anita C ChalmersSchool of Environmental and Life Sciences, University of Newcastle, 10 Chittaway Rd, Ourimbah, NSW, 2258, Australia.
Ian A van AltenaSchool of Environmental and Life Sciences, University of Newcastle, 10 Chittaway Rd, Ourimbah, NSW, 2258, Australia.
Michael C BowyerPancreatic Cancer Research Group, School of Environmental and Life Sciences, University of Newcastle, 10 Chittaway Rd, Ourimbah, NSW, 2258, Australia.
Christopher J ScarlettPancreatic Cancer Research Group, School of Environmental and Life Sciences, University of Newcastle, 10 Chittaway Rd, Ourimbah, NSW, 2258, Australia. c.scarlett@newcastle.edu.au.
Hunter Water · AUCalvary Mater Newcastle Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In spite of the recent advancements in oncology, the overall survival rate for pancreatic cancer has not improved over the last five decades. Eucalypts have been linked with cytotoxic and anticancer properties in various studies; however, there is very little scientific evidence that supports the direct role of eucalypts in the treatment of pancreatic cancer. This study assessed the anticancer properties of aqueous and ethanolic extracts of four Eucalyptus species using an MTT assay. The most promising extracts were further evaluated using a CCK-8 assay. Apoptotic studies were performed using a caspase 3/7 assay in MIA PaCa-2 cells. The aqueous extract of Eucalyptus microcorys leaf and the ethanolic extract of Eucalyptus microcorys fruit inhibited the growth of glioblastoma, neuroblastoma, lung and pancreatic cancer cells by more than 80% at 100 μg/mL. The E. microcorys and Eucalyptus saligna extracts showed lower GI

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationCell ShapeCell SurvivalDeoxycytidineEucalyptusGemcitabineHumansInhibitory Concentration 50Plant ExtractsAntineoplastic AgentsDeoxycytidineGemcitabinePlant ExtractsAnticancerCaspase 3/7CCK-8EucalyptusMTTPancreatic cancer

Identifiers

PMID28452004
OpenAlexW2608539324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.