ArticleClinical oral investigations2018
Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism.
Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Analysis of genetic polymorphisms and mRNA expression of DRD3 and HTR2A in bruxism.BMC oral health · 2026Observational
- Bruxism in children and adolescents with attention deficit hyperactivity disorder due to medication regimen: prevalence, correlates, and consequences a cross-sectional study.European oral research · 2026Article
- The importance of dopamine levels and single-nucleotide polymorphism withinAnnals of medicine · 2025Article
- Family history of bruxism: a case-control study based on the ecological momentary assessment of awake bruxism.Journal of oral & facial pain and headache · 2025Article
- Understanding the clinical management of co-occurring sleep-related bruxism and obstructive sleep apnea in adults: A narrative and critical review.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025Review
- The Importance of Genetic Background and Neurotransmission in the Pathogenesis of the Co-Occurrence of Sleep Bruxism and Sleep-Disordered Breathing-Review of a New Perspective.Journal of clinical medicine · 2024Review
- Clenching the Strings of Bruxism Etiopathogenesis: Association Analyses on Genetics and Environmental Risk Factors in a Deeply Characterized Italian Cohort.Biomedicines · 2024Article
- Sleep Bruxism in Children: A Narrative Review.Current pediatric reviews · 2024Review
- Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses.Frontiers in neurology · 2024Article
- The neural substrates of bruxism: current knowledge and clinical implications.Frontiers in neurology · 2024Review
- Sleep bruxism in children, from evidence to the clinic. A systematic review.Frontiers in oral health · 2023Review
- Immediate Evaluation of the Effect of Infrared LED Photobiomodulation on Childhood Sleep Bruxism: A Randomized Clinical Trial.Life (Basel, Switzerland) · 2022Article
- Temporomandibular disorders in patients with polysomnographic diagnosis of sleep bruxism: a case-control study.Sleep & breathing = Schlaf & Atmung · 2022Article
- The dental demolition derby: bruxism and its impact - part 1: background.British dental journal · 2022Article
- Ischemic Stroke and Sleep: The Linking Genetic Factors.Cardiology and therapy · 2021Review
- Polymorphic variants in genes related to stress coping are associated with the awake bruxism.BMC oral health · 2021Article
- The Genetics of Sleep Disorders in Children: A Narrative Review.Brain sciences · 2021Review
- Oral Manifestations of Wolf-Hirschhorn Syndrome: Genotype-Phenotype Correlation Analysis.Journal of clinical medicine · 2020Article
- Bruxism Throughout the Lifespan and Variants inJournal of personalized medicine · 2020Article
- Understanding the Scientific Basis of Post-traumatic Stress Disorder (PTSD): Precision Behavioral Management Overrides Stigmatization.Molecular neurobiology · 2019Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThis research aimed to evaluate the frequency of single nucleotide polymorphisms (SNPs) in dopaminergic pathway genes (DRD1, DRD2, DRD3, DRD4, DRD5, and MAOB) in patients undergoing bruxism treatment and controls. SUBJECTS AND
methodsPatients submitted to bruxism treatment were classified in awake bruxism (61 patients), sleep bruxism (26 patients), and awake-sleep bruxism (43 patients). Control group included 59 patients. Association between circadian manifestations of bruxism and SNPs was investigated using Fisher's exact test, chi-squared test, and calculating the odds ratios and their respective 95% confidence intervals.
resultsThe G allele of DRD2 rs1800497 SNP was associated with a significant risk reduction of awake-sleep bruxism (p = 0.041), while the C allele of DRD3 rs6280 SNP was associated with increased risk of sleep bruxism (p = 0.02), and the C allele of DRD5 rs6283 SNP was associated with decreased risk of awake bruxism (p = 0.01).
conclusionsTo our knowledge, this is the first report exploring the contribution of genetic variants in dopaminergic pathways to bruxism development, considering all circadian manifestations. Our findings indicate a possible genetic influence in the etiology of awake, sleep, and awake-sleep bruxism. Therefore, further research is needed to increase the current understanding of bruxism physiopathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.