ArticleBiogerontology2017
Mifepristone/RU486 acts in Drosophila melanogaster females to counteract the life span-shortening and pro-inflammatory effects of male Sex Peptide.
Article in Biogerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Article
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- How does a fly die? Insights into ageing from the pathophysiology of Drosophila mortality.GeroScience · 2024Review
- Pharmacology of Aging:Aging biology · 2024Article
- Conditional Inhibition of Eip75B Eliminates the Effects of Mating and Mifepristone on Lifespan in FemaleCells · 2024Article
- Decoupled evolution of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Decoupled evolution of thebioRxiv : the preprint server for biology · 2023Article
- Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis.Disease models & mechanisms · 2023Article
- Sex-biased gene expression in nutrient-sensing pathways.Proceedings. Biological sciences · 2023Article
- Article
- Article
- The evolution of sex peptide: sexual conflict, cooperation, and coevolution.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Mifepristone Increases Life Span in FemaleFrontiers in aging · 2022Article
- Alterations in brain glycogen levels influence life-history traits and reduce the lifespan in female Drosophila melanogaster.Biology open · 2021Article
- Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Mifepristone Increases Life Span of Virgin FemaleFrontiers in genetics · 2021Article
- Sex differences in the response to oxidative and proteolytic stress.Redox biology · 2020Review
- Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster.BMC systems biology · 2019Article
- Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Males with null mutation of Sex Peptide (SP) gene were compared to wild-type males for the ability to cause physiological changes in females that could be reversed by mifepristone. Males from wild-type strains decreased median female life span by average -51%. Feeding mifepristone increased life span of these females by average +106%. In contrast, SP-null males did not decrease female life span, and mifepristone increased median life span of these females by average +14%, which was equivalent to the effect of mifepristone in virgin females (average +16%). Expression of innate immune response transgenic reporter (Drosocin-GFP) was increased in females mated to wild-type males, and this expression was reduced by mifepristone. In contrast, SP-null males did not increase Drosocin-GFP reporter expression in the female. Similarly, mating increased endogenous microbial load, and this effect was reduced or absent in females fed mifepristone and in females mated to SP-null males; no loss of intestinal barrier integrity was detected using dye-leakage assay. Reduction of microbial load by treating adult flies with doxycycline reduced the effects of both mating and mifepristone on life span. Finally, mifepristone blocked the negative effect on life span caused by transgenic expression of SP in virgin females. The data support the conclusion that the majority of the life span-shortening, immune-suppressive and pro-inflammatory effects of mating are due to male SP, and demonstrate that mifepristone acts in females to counteract these effects of male SP.
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