SynthesisEuropean journal of nuclear medicine and molecular imaging2017
Accuracy of diagnostic imaging modalities for peripheral post-traumatic osteomyelitis - a systematic review of the recent literature.
Synthesis in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- EANM/SNMMI guideline/procedure standard for [European journal of nuclear medicine and molecular imaging · 2025Guideline
- Comparative diagnostic accuracy of respective nuclear imaging for suspected fracture-related infection: a systematic review and Bayesian network meta-analysis.Archives of orthopaedic and trauma surgery · 2021Pooled it
- In vivo bacteria-targeted imaging with vancomycin-based positron emission tomography and optical tracers in an orthopaedic trauma implant infection model.European journal of nuclear medicine and molecular imaging · 2026Article
- Diagnostic accuracy of radiolabelled-WBC scintigraphy in patients with antibiotic therapy.European journal of nuclear medicine and molecular imaging · 2026Article
- The differential diagnostic potential of SPECT/CT to detect osteomyelitis in foot or ankle: a systematic review.EFORT open reviews · 2025Article
- Bacterial Osteomyelitis in the Lower Extremities: Analysis of Histology and MRI Findings in a Case-Control Pilot Study.Journal of clinical medicine · 2025Article
- Bacteria-targeted imaging using vancomycin-based positron emission tomography tracers can distinguish infection from sterile inflammation.European journal of nuclear medicine and molecular imaging · 2025Article
- Diagnostic Value of Increased [18F]FDG Uptake in Locoregional Lymph Nodes on PET/CT in Patients with Suspected Fracture-Related Infection.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Medical imaging diagnosis of orthopedic prosthesis-associated infections: a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Article
- Case Report: Osteomyelitis in a giant panda (Frontiers in veterinary science · 2025Article
- Article
- FRID-PI: a machine learning model for diagnosing fracture-related infections based onFrontiers in medicine · 2025Article
- Future directions for early detection of fracture related infections.Journal of orthopaedics · 2024Article
- Synthesis and preclinical evaluation of novelEuropean journal of nuclear medicine and molecular imaging · 2024Article
- Pathogens in FRI - Do bugs matter? - An analysis of FRI studies to assess your enemy.Journal of orthopaedics · 2024Article
- Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects.Journal of clinical medicine · 2024Review
- Bones on fire: illuminating osteomyelitis through the radiant lens ofFrontiers in immunology · 2024Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsPost-traumatic osteomyelitis (PTO) is difficult to diagnose and there is no consensus on the best imaging strategy. The aim of this study is to present a systematic review of the recent literature on diagnostic imaging of PTO.
methodsA literature search of the EMBASE and PubMed databases of the last 16 years (2000-2016) was performed. Studies that evaluated the accuracy of magnetic resonance imaging (MRI), three-phase bone scintigraphy (TPBS), white blood cell (WBC) or antigranulocyte antibody (AGA) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and plain computed tomography (CT) in diagnosing PTO were considered for inclusion. The review was conducted using the PRISMA statement and QUADAS-2 criteria.
resultsThe literature search identified 3358 original records, of which 10 articles could be included in this review. Four of these studies had a comparative design which made it possible to report the results of, in total, 17 patient series. WBC (or AGA) scintigraphy and FDG-PET exhibit good accuracy for diagnosing PTO (sensitivity ranged from 50-100%, specificity ranged from 40-97% versus 83-100% and 51%-100%, respectively). The accuracy of both modalities improved when a hybrid imaging technique (SPECT/CT & FDG-PET/CT) was performed. For FDG-PET/CT, sensitivity ranged between 86 and 94% and specificity between 76 and 100%. For WBC scintigraphy + SPECT/CT, this is 100% and 89-97%, respectively.
conclusionsBased on the best available evidence of the last 16 years, both WBC (or AGA) scintigraphy combined with SPECT/CT or FDG-PET combined with CT have the best diagnostic accuracy for diagnosing peripheral PTO.
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