SynthesisWorld journal of surgery2017
Clinicopathological Significance and Prognosis of Medullary Thyroid Microcarcinoma: A Meta-analysis.
Synthesis in World journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Risk factors for lateral cervical lymph node metastasis in medullary thyroid carcinoma.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021Pooled it
- Medullary Thyroid Carcinoma Detected by Routine Health Screening Had Better Clinical Outcome and Survival.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Clinicopathological characteristics, prognosis, and the significance of FNA-CT in sporadic medullary thyroid microcarcinoma: a 10-year retrospective study.Frontiers in endocrinology · 2025Article
- Prognosis analysis and nomogram for predicting lateral lymph node metastasis in Medullary Thyroid Microcarcinoma.Langenbeck's archives of surgery · 2024Article
- Clinicopathological characteristics and prognosis of medullary thyroid microcarcinoma: a tumor with a similar prognosis to macrocarcinoma.European journal of medical research · 2023Article
- Natural History and Predictive Factors of Outcome in Medullary Thyroid Microcarcinoma.The Journal of clinical endocrinology and metabolism · 2023Article
- Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.Endocrine pathology · 2023Review
- Partial preservation of the normal thyroid gland based on tumor diameter may be possible in small medullary thyroid carcinoma: a two-center 15-year retrospective study.Frontiers in oncology · 2023Article
- Cytology versus calcitonin assay in fine-needle aspiration biopsy wash-out fluid (FNAB-CT) in diagnosis of medullary thyroid microcarcinoma.Endocrine · 2021Article
- Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis.Therapeutic advances in endocrinology and metabolism · 2021Review
- Trends in the Diagnosis and Treatment of Patients with Medullary Thyroid Carcinoma in Korea.Endocrinology and metabolism (Seoul, Korea) · 2020Article
- Cure and survival of sporadic medullary thyroid carcinoma following systematic preoperative calcitonin screening.Langenbeck's archives of surgery · 2019Article
- Comprehensive evaluation of medullary thyroid carcinoma before surgery.Chinese medical journal · 2019Article
- Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules <10 mm in the maximum diameter: does size matter?Cancer management and research · 2019Article
- Static Prognostic Factors and Appropriate Surgical Designs for Patients with Medullary Thyroid Carcinoma: The Second Report from a Single-Institution Study in Japan.World journal of surgery · 2018Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of the present meta-analysis was to evaluate the clinicopathological significance and prognosis of micro-MTC compared to macro-MTC.
methodsRelevant articles were obtained by searching the PubMed and MEDLINE databases. A meta-analysis was performed using 15 eligible studies. In addition, subgroup analysis based on heredity was performed in patients diagnosed with micro-MTC.
resultsThe rate of extrathyroidal extension of micro-MTC [0.118 (95% CI 0.073-0.185)] was significantly lower than that of macro-MTC [0.303 (95% CI 0.224-0.395)]. Micro-MTC [0.229 (95% CI 0.161-0.314)] had a significantly lower rate of cervical lymph node (LN) metastasis compared to macro-MTC [0.595 (95% CI 0.486-0.694)]. The rate of multifocality was not significantly different between micro-MTC and macro-MTC [0.394 (95% CI 0.244-0.566) vs. 0.320 (95% CI 0.234-0.421), respectively]. The rate of distant metastasis did not differ significantly between micro-MTC [0.082 (95% CI 0.017-0.314)] and macro-MTC [0.068 (95% CI 0.009-0.376)]. Patients with micro-MTC showed significantly higher disease-free survival rates [hazard ratio [HR] 0.406 (95% CI 0.288-0.575), I
conclusionMicro-MTC has aggressive features, such as multifocality and distant metastasis, similar to macro-MTC and a non-negligible rate of extrathyroidal extension and cervical LN metastasis. We suggest that treatment of micro-MTC should be approached with a similar focus as that of macro-MTC. Considering that less extrathyroidal extension and cervical LN metastasis occur in patients with micro-MTC compared to macro-MTC, we propose that treatment of micro-MTC, which has a relatively low disease burden status, should be viewed as an opportunity for improving prognosis.
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