ArticlePlanta2017
Functional characterization of the pinoresinol-lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response.
Article in Planta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Insights into the functional characterization of DIR proteins through genome-wide in silico and evolutionary studies: a systematic review.Functional & integrative genomics · 2023Pooled it
- Changes in the expression of microRNAs regulate podophyllotoxin accumulation in Linum album cells to phenylalanine.BMC plant biology · 2026Article
- Molecular Mechanisms of Lignans in Lowering Blood Pressure and Anti-Obesity Effects: A Review.Foods (Basel, Switzerland) · 2026Review
- Unveiling the Power of Flax Lignans: From Plant Biosynthesis to Human Health Benefits.Nutrients · 2024Review
- Phenolic Compound Profile and Antioxidant Capacity of Flax (Molecules (Basel, Switzerland) · 2023Article
- Transgenic Forsythia plants expressing sesame cytochrome P450 produce beneficial lignans.Scientific reports · 2022Article
- Transcriptome analyses reveal the expression profile of genes related to lignan biosynthesis inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Physiological, biochemical, and molecular responses ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Genes Associated with the Flax Plant Type (Oil or Fiber) Identified Based on Genome and Transcriptome Sequencing Data.Plants (Basel, Switzerland) · 2021Article
- NMR and LC-MS-Based Metabolomics to Study Osmotic Stress in Lignan-Deficient Flax.Molecules (Basel, Switzerland) · 2021Article
- Feasible Production of Lignans and Neolignans in Root-derived In Vitro Cultures of Flax (Plants (Basel, Switzerland) · 2020Article
- Article
- Piriformospora indica cell wall modulates gene expression and metabolite profile in Linum album hairy roots.Planta · 2018Article
- Seed coats as an alternative molecular factory: thinking outside the box.Plant reproduction · 2018Review
- A genome-wide analysis of the flax (Linum usitatissimum L.) dirigent protein family: from gene identification and evolution to differential regulation.Plant molecular biology · 2018Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAIN
conclusionThis study provides new insights into the biosynthesis regulation and in planta function of the lignan yatein in flax leaves. Pinoresinol-lariciresinol reductases (PLR) catalyze the conversion of pinoresinol into secoisolariciresinol (SECO) in lignan biosynthesis. Several lignans are accumulated in high concentrations, such as SECO accumulated as secoisolariciresinol diglucoside (SDG) in seeds and yatein in aerial parts, in the flax plant (Linum usitatissimum L.) from which two PLR enzymes of opposite enantioselectivity have been isolated. While LuPLR1 catalyzes the biosynthesis of (+)-SECO leading to (+)-SDG in seeds, the role(s) of the second PLR (LuPLR2) is not completely elucidated. This study provides new insights into the in planta regulation and function of the lignan yatein in flax leaves: its biosynthesis relies on a different PLR with opposite stereospecificity but also on a distinct expression regulation. RNAi technology provided evidence for the in vivo involvement of the LuPLR2 gene in the biosynthesis of (-)-yatein accumulated in flax leaves. LuPLR2 expression in different tissues and in response to stress was studied by RT-qPCR and promoter-reporter transgenesis showing that the spatio-temporal expression of the LuPLR2 gene in leaves perfectly matches the (-)-yatein accumulation and that LuPLR2 expression and yatein production are increased by methyl jasmonate and wounding. A promoter deletion approach yielded putative regulatory elements. This expression pattern in relation to a possible role for this lignan in flax defense is discussed.
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