Evidence map›Paper›PMID 28451646›Full record

ArticleJACC. Clinical electrophysiology2016

Chronotropic Incompetence and Risk of Atrial Fibrillation: The Henry Ford ExercIse Testing (FIT) Project.

Wesley T O'Neal, Waqas T Qureshi, Michael J Blaha, Zeina A Dardari, Jonathan K Ehrman, Clinton A Brawner, Elsayed Z Soliman, Mouaz H Al-Mallah

Open access · greenAbstract read
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In one paragraph

Article in JACC. Clinical electrophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
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  4. Initial heart rate score predicts new-onset atrial tachyarrhythmias in pacemaker patients.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Wesley T O'NealDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Waqas T QureshiDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Michael J BlahaJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Zeina A DardariJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Jonathan K EhrmanDivision of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.
Clinton A BrawnerDivision of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.
Elsayed Z SolimanDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Mouaz H Al-MallahDivision of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.
Henry Ford Hospital · USWake Forest University · USJohns Hopkins University · US

Funding

CVD Epidemiology Training ProgramT32HL076132 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAVID McLeod HERRINGTON · 2004 to 2026
$8.4M
NHLBI NIH HHS T32 HL076132
6 · The paper itself

Abstract

objectivesTo examine the association between chronotropic incompetence and incident atrial fibrillation (AF).

backgroundPatients with inadequate heart rate response during exercise may have abnormalities in sinus node function or autonomic tone that predispose to the development of AF.

methodsWe examined the association between heart rate response and incident AF in 57,402 (mean age=54±13 years, 47% female, 64% white) patients free of baseline AF who underwent exercise-treadmill stress testing from the Henry Ford ExercIse Testing (FIT) Project. Age-predicted maximum heart rate (pMHR) values <85% and chronotropic index values <80% were used to define chronotropic incompetence. Cox regression, adjusting for demographics, cardiovascular risk factors, medications, coronary heart disease, heart failure, and metabolic equivalent of task achieved, was used to compute hazard ratios (HR) and 95% confidence intervals (CI) for the association between chronotropic incompetence and incident AF.

resultsOver a median follow-up of 5.0 years (25

conclusionsOur analysis suggests that patients with inadequate heart rate response during exercise have an increased risk for developing AF.

Indexed as

atrial fibrillationchronotropic incompetencerisk factors

Identifiers

PMID28451646
PMCPMC5403158
OpenAlexW2472837637

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.