Evidence map›Paper›PMID 28451631›Full record

ArticleeNeuro

GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the

D Sinclair, R Featherstone, M Naschek, J Nam, A Du, S Wright, K Pance, O Melnychenko, R Weger, S Akuzawa and 2 more

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Auditory processing in rodent models of autism: a systematic review.Journal of neurodevelopmental disorders · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

D SinclairTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5961-1007
R FeatherstoneTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
M NaschekTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
J NamTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
A DuTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
S WrightTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
K PanceTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-0983-8347
O MelnychenkoTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-5135-9844
R WegerTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
S AkuzawaNeuroscience Research Unit, DDR, Astellas Pharma Inc., Tsukuba-Shi, Ibaraki 305-8585, Japan.
M MatsumotoNeuroscience Research Unit, DDR, Astellas Pharma Inc., Tsukuba-Shi, Ibaraki 305-8585, Japan.ORCID 0000-0002-1172-2354
S J SiegelTranslational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8058-9713
California University of Pennsylvania · USAstellas Pharma (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fragile X syndrome is a genetic condition resulting from

Indexed as

Acoustic StimulationAnimalsBaclofenDisease Models, AnimalElectroencephalographyEvoked Potentials, AuditoryExploratory BehaviorFemaleFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeGABA-B Receptor AgonistsInterpersonal RelationsMaleMaze LearningMemory, Short-TermMental DisordersBaclofenFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1GABA-B Receptor AgonistsEEGfragile X syndromeGABAgammaracemic baclofenworking memory

Identifiers

PMID28451631
PMCPMC5394929
OpenAlexW2587835308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.