ArticleClinical psychological science : a journal of the Association for Psychological Science2017
Blunted reward processing in remitted melancholic depression.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Actigraphically measured psychomotor slowing in depression: systematic review and meta-analysis.Psychological medicine · 2022Pooled it
- Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies.The American journal of psychiatry · 2018Pooled it
- Behavioral and electrophysiological evidence of reward processing deficits in repetitive negative thinking: Implications for depression.Psychological medicine · 2026Trial
- Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment.The Journal of clinical psychiatry · 2018Trial
- Trial
- Suicide attempt history is associated with blunted neural reward responsiveness after accounting for a history of suicidal ideation and preparatory behaviors.Cognitive, affective & behavioral neuroscience · 2026Article
- Opposing Relations of Reward Positivity with Anhedonia and Threat Sensitivity: Implications for Differential Dimensional Diagnosis.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Left Ventrolateral Prefrontal Cortical Activity During Reward Expectancy and Mania Risk.JAMA psychiatry · 2025Article
- Machine learning reveals differential effects of depression and anxiety on reward and punishment processing.Scientific reports · 2024Article
- Cognitive inflexibility and heightened error monitoring are related to lower sexual functioning.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Stressful Life Events and Reward Processing in Adults: Moderation by Depression and Anhedonia.Depression and anxiety · 2024Article
- Aberrant high-beta band functional connectivity during reward processing in melancholic major depressive disorder: An MEG study.NeuroImage. Clinical · 2024Article
- Uncovering the Neural Correlates of Anhedonia Subtypes in Major Depressive Disorder: Implications for Intervention Strategies.Biomedicines · 2023Article
- Childhood trauma predicts blunted error monitoring in adulthood: An event-related potential study.Cognitive, affective & behavioral neuroscience · 2023Article
- Risk factors for the intergenerational transmission of depression in women and girls: Understanding neural correlates of major depressive disorder and the role of early-onset maternal depression.Cognitive, affective & behavioral neuroscience · 2023Article
- Self-referential Processing in Remitted Depression: An Event-Related Potential Study.Biological psychiatry global open science · 2023Article
- Rethinking the risk for depression using the RDoC: A psychophysiological perspective.Frontiers in psychology · 2023Review
- Examining the Construct Validity of Borderline Personality Traits Using Familial Aggregation and Other External Validators.Journal of personality disorders · 2022Article
- Revisiting the seven pillars of RDoC.BMC medicine · 2022Article
- Maternal suicidality interacts with blunted reward processing to prospectively predict increases in depressive symptoms in 8-to-14-year-old girls.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Blunted reward response appears to be a trait-like marker of vulnerability for Major Depressive Disorder (MDD). As such, it should be present in remitted individuals; however, depression is a heterogeneous syndrome. Reward-related impairments may be more pronounced in individuals with melancholic depression. The present study examined neural responses to rewards in remitted melancholic depression (rMD; N = 29), remitted non-melancholic depression (rNMD; N = 56), and healthy controls (HC; N = 81). Event-related potentials to monetary gain and loss were recorded during a simple gambling paradigm. rMD was characterized by a blunted response to rewards relative to both the HC and the rNMD groups, who did not differ from one another. Moreover, the rMD and rNMD groups did not differ in course or severity of their past illnesses, or current depressive symptoms or functioning. Results suggest that blunted response to rewards may be a viable vulnerability marker for melancholic depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.