Evidence map›Paper›PMID 28451449›Full record

ArticleESC heart failure2017

Benefit of tolvaptan in the management of hyponatraemia in patients with diuretic-refractory congestive heart failure: the SEMI-SEC project.

Antonio Pose, Luis Almenar, Juan José Gavira, Amador López-Granados, Teresa Blasco, Juan Delgado, Oscar Aramburu, Avelino Rodríguez, Luis Manzano, Nicolás Manito

Open access · goldAbstract read
In one paragraph

Article in ESC heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Prognostic effect of a vasopressin VEuropean journal of clinical pharmacology · 2024
    Article
  3. Combinational Diuretics in Heart Failure.Current heart failure reports · 2024
    Review
  4. Tolvaptan Improves Contrast-Induced Acute Kidney Injury.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2022
    Article
  5. Administration of Subcutaneous Furosemide in Elastomeric Pump vs. Oral Solution for the Treatment of Diuretic Refractory Congestion.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021
    Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 1 country.

Antonio PoseDepartment of Internal MedicineComplexo Hospitalario Universitario de Santiago de CompostelaLa CoruñaSpain.
Luis AlmenarCardiology DepartmentHospital Universitario y Politécnico La FeValenciaSpain.
Juan José GaviraCardiology DepartmentClínica Universitaria de NavarraPamplonaSpain.
Amador López-GranadosCardiology DepartmentHospital Universitario Reina SofíaCordobaSpain.
Teresa BlascoCardiology DepartmentHospital Miguel ServetZaragozaSpain.
Juan DelgadoCardiology DepartmentHospital Universitario 12 de OctubreMadridSpain.
Oscar AramburuDepartment of Internal MedicineHospital Universitario Virgen de la MacarenaSevilleSpain.
Avelino RodríguezDepartment of Internal MedicineComplexo Hospitalario Universitario de VigoPontevedraSpain.
Luis ManzanoDepatment of Internal MedicineHospital Universitario Ramón y CajalMadridSpain.
Nicolás ManitoCardiology DepartmentHospital Universitario de BellvitgeBarcelonaSpain.
Bellvitge University Hospital · ESClinica Universidad de Navarra · ESComplexo Hospitalario Universitario A Coruña · ESHospital Universitari i Politècnic La Fe · ESHospital Universitario 12 De Octubre · ESHospital Universitario Miguel Servet · ESHospital Universitario Ramón y Cajal · ESHospital Universitario Reina Sofía · ESHospital Universitario Virgen Macarena · ESUniversity Hospital Complex Of Vigo · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsHyponatraemia is an electrolyte disorder that occurs in advanced congestive heart failure (HF) and worsens prognosis. We explored the usefulness of tolvaptan, which has shown promising results in the treatment of this condition. METHODS AND

resultsThis study is based on a retrospective national registry (2011-15) of patients hospitalized with refractory HF and hyponatraemia who agreed to receive tolvaptan when standard treatment was ineffective. The benefit of tolvaptan was analysed according to the following criteria: normalization ([Na

conclusionsAn increase in sodium levels and/or improvement in urine output was observed in patients admitted for HF and refractory hyponatraemia under tolvaptan treatment. Tolvaptan may be useful in this setting, in which no effective proven alternatives are available.

Indexed as

Congestive heart failureDiuresisHyponatraemiaTolvaptanVasopressin type 2 receptors

Identifiers

PMID28451449
PMCPMC5396041
OpenAlexW2576187722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.