Evidence map›Paper›PMID 28451353›Full record

ArticleChemical science2017

Highly specific noninvasive photoacoustic and positron emission tomography of brain plaque with functionalized croconium dye labeled by a radiotracer.

Yajing Liu, Yanping Yang, Mingjian Sun, Mengchao Cui, Ying Fu, Yu Lin, Zijing Li, Liming Nie

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 77 citations in OpenAlex.

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  15. Photoacoustics · 2021
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals.Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yajing LiuState Key Laboratory of Molecular Vaccinology , Molecular Diagnosis & Center for Molecular Imaging and Translational Medicine , School of Public Health , Xiamen University , Xiamen 361102 , People's Republic of China . Email: zijing.li@xmu.edu.cn ; Email: nielm@xmu.edu.cn.
Yanping YangKey Laboratory of Radiopharmaceuticals , Ministry of Education , College of Chemistry , Beijing Normal University , Beijing 100875 , China.
Mingjian SunDepartment of Control Science and Engineering , Harbin Institute of Technology , 92 West Dazhi Street, Nan Gang District , Harbin 150001 , China.
Mengchao CuiKey Laboratory of Radiopharmaceuticals , Ministry of Education , College of Chemistry , Beijing Normal University , Beijing 100875 , China.
Ying FuDepartment of Control Science and Engineering , Harbin Institute of Technology , 92 West Dazhi Street, Nan Gang District , Harbin 150001 , China.
Yu LinState Key Laboratory of Molecular Vaccinology , Molecular Diagnosis & Center for Molecular Imaging and Translational Medicine , School of Public Health , Xiamen University , Xiamen 361102 , People's Republic of China . Email: zijing.li@xmu.edu.cn ; Email: nielm@xmu.edu.cn.
Zijing LiState Key Laboratory of Molecular Vaccinology , Molecular Diagnosis & Center for Molecular Imaging and Translational Medicine , School of Public Health , Xiamen University , Xiamen 361102 , People's Republic of China . Email: zijing.li@xmu.edu.cn ; Email: nielm@xmu.edu.cn.
Liming NieState Key Laboratory of Molecular Vaccinology , Molecular Diagnosis & Center for Molecular Imaging and Translational Medicine , School of Public Health , Xiamen University , Xiamen 361102 , People's Republic of China . Email: zijing.li@xmu.edu.cn ; Email: nielm@xmu.edu.cn.ORCID 0000-0002-1781-4612
Xiamen University · CNBeijing Normal University · CNHarbin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly-efficient targeting probes are desirable for disease diagnosis and functional imaging. However, most of the current near-infrared (NIR) probes suffer from low signal conversion, insufficient photostability, poor probe specificity, and limited functions. Herein, an NIR ultrahigh absorbing croconium dye for amyloid (CDA) was designed and synthesized to specifically bind to cerebrovascular amyloid without antibody linkage. This unique CDA is able to strongly bind the hydrophobic channels of amyloid beta (Aβ) fiber with a very strong binding energy of -9.3 kcal mol

Identifiers

PMID28451353
PMCPMC5399633
OpenAlexW2575056215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.