ArticleChemical science2017
Protein-based fluorescent nanoparticles for super-resolution STED imaging of live cells.
Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Super-Resolution Structured Illumination Microscopy to Study Endocytosis and Cellular Nanoparticle Uptake.ACS nano · 2026Review
- Recent Advances in Fluorescent Nanoparticles for Stimulated Emission Depletion Imaging.Biosensors · 2024Review
- Ligand-protected nanocluster-mediated photoswitchable fluorescent nanoprobes towards dual-color cellular imaging.Chemical science · 2023Article
- Fluorescent Nanoparticles for Super-Resolution Imaging.Chemical reviews · 2022Review
- Hysteresis and Stochastic Fluorescence by Aggregated Ensembles of Graphene Quantum Dots.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
- Nanoscopy for endosomal escape quantification.Nanoscale advances · 2021Review
- Espin distribution as revealed by super-resolution microscopy of stereocilia.American journal of translational research · 2020Article
- Nano- and microparticles at fluid and biological interfaces.Journal of physics. Condensed matter : an Institute of Physics journal · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Development of nanoparticles for super-resolution imaging (sriNPs) can greatly enrich the toolbox of robust optical probes for biological studies. Moreover, sriNPs enable us to monitor the behavior of engineered nanomaterials in complex biological environments with high spatial resolution, which is important for advancing our understanding of nano-bio interactions. Up to now, reports on sriNPs have been scarce. In this work, we report a facile strategy to prepare protein-based fluorescent NPs that can be utilized as probes in super-resolution microscopy. The method is simple and straightforward, and easily extendible to other types of fluorophores. By using Atto647N-transferrin NPs as an example, we have achieved a roughly four-fold resolution improvement by using STED nanoscopy. These protein-based sriNPs possess excellent biocompatibility, good colloidal stability and photostability, making them attractive candidates for biological studies. Moreover, STED nanoscopy enables the precise imaging of NP structures in living cells, and revealed the co-existence of multiple NPs within one endosomal vesicle.
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Registered trials
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