Evidence map›Paper›PMID 28451298›Full record

ArticleChemical science2017

Enrichment and single-cell analysis of circulating tumor cells.

Yanling Song, Tian Tian, Yuanzhi Shi, Wenli Liu, Yuan Zou, Tahereh Khajvand, Sili Wang, Zhi Zhu, Chaoyong Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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  15. Spatially resolved transcriptomics provide a new method for cancer research.Journal of experimental & clinical cancer research : CR · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanling SongMOE Key Laboratory of Spectrochemical Analysis & Instrumentation , The Key Laboratory of Chemical Biology of Fujian Province , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemical Engineering , Department of Chemical Biology , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email: cyyang@xmu.edu.cn.
Tian TianMOE Key Laboratory of Spectrochemical Analysis & Instrumentation , The Key Laboratory of Chemical Biology of Fujian Province , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemical Engineering , Department of Chemical Biology , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email: cyyang@xmu.edu.cn.
Yuanzhi ShiMOE Key Laboratory of Spectrochemical Analysis & Instrumentation , The Key Laboratory of Chemical Biology of Fujian Province , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemical Engineering , Department of Chemical Biology , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email: cyyang@xmu.edu.cn.
Wenli LiuMOE Key Laboratory of Spectrochemical Analysis & Instrumentation , The Key Laboratory of Chemical Biology of Fujian Province , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemical Engineering , Department of Chemical Biology , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email: cyyang@xmu.edu.cn.
Yuan ZouMOE Key Laboratory of Spectrochemical Analysis & Instrumentation , The Key Laboratory of Chemical Biology of Fujian Province , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemical Engineering , Department of Chemical Biology , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email: cyyang@xmu.edu.cn.
Tahereh KhajvandMOE Key Laboratory of Spectrochemical Analysis & Instrumentation , The Key Laboratory of Chemical Biology of Fujian Province , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemical Engineering , Department of Chemical Biology , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email: cyyang@xmu.edu.cn.
Sili WangDepartment of Hematology , The First Affiliated Hospital of Xiamen University , Xiamen 361005 , China.
Zhi ZhuMOE Key Laboratory of Spectrochemical Analysis & Instrumentation , The Key Laboratory of Chemical Biology of Fujian Province , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemical Engineering , Department of Chemical Biology , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email: cyyang@xmu.edu.cn.
Chaoyong YangMOE Key Laboratory of Spectrochemical Analysis & Instrumentation , The Key Laboratory of Chemical Biology of Fujian Province , State Key Laboratory of Physical Chemistry of Solid Surfaces , Collaborative Innovation Center of Chemistry for Energy Materials , Department of Chemical Engineering , Department of Chemical Biology , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email: cyyang@xmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to 90% of cancer-related deaths are caused by metastatic cancer. Circulating tumor cells (CTCs), a type of cancer cell that spreads through the blood after detaching from a solid tumor, are essential for the establishment of distant metastasis for a given cancer. As a new type of liquid biopsy, analysis of CTCs offers the possibility to avoid invasive tissue biopsy procedures with practical implications for diagnostics. The fundamental challenges of analyzing and profiling CTCs are the extremely low abundances of CTCs in the blood and the intrinsic heterogeneity of CTCs. Various technologies have been proposed for the enrichment and single-cell analysis of CTCs. This review aims to provide in-depth insights into CTC analysis, including various techniques for isolation of CTCs with capture methods based on physical and biochemical principles, and single-cell analysis of CTCs at the genomic, proteomic and phenotypic level, as well as current developmental trends and promising research directions.

Identifiers

PMID28451298
PMCPMC5396552

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.