ArticleChemical science2017
Reversible ratiometric detection of highly reactive hydropersulfides using a FRET-based dual emission fluorescent probe.
Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 84 citations in OpenAlex.
- Role of hydrogen sulfide in bacterial antibiotic tolerance: from mechanisms to therapeutic targeting.Frontiers in cellular and infection microbiology · 2026Review
- Dual-quartet phosphorescent emission in the open-shell MNature communications · 2024Article
- Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species.Chemical reviews · 2024Review
- A Reversible Dual-Channel Near-Infrared Flavonoid Probe forChemical & biomedical imaging · 2023Article
- Two triplet emitting states in one emitter: Near-infrared dual-phosphorescent AuScience advances · 2023Article
- A Review of Chemical Tools for Studying Small Molecule Persulfides: Detection and Delivery.ACS chemical biology · 2021Review
- S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease.Antioxidants & redox signaling · 2020Review
- Engineering a highly selective probe for ratiometric imaging of HChemical science · 2020Article
- A smartphone based device for the detection of sulfane sulfurs in biological systems.Sensors and actuators. B, Chemical · 2019Article
- Fluorescent probes guided by a new practical performance regulation strategy to monitor glutathione in living systems.Chemical science · 2018Article
- Fluorescent Probes Based on π-Conjugation Modulation between Hemicyanine and Coumarin Moieties for Ratiometric Detection of pH Changes in Live Cells with Visible and Near-infrared Channels.Sensors and actuators. B, Chemical · 2018Article
- A fluorescentChemical science · 2018Article
- Ratiometric Near-Infrared Fluorescent Probes Based On Through-Bond Energy Transfer and π-Conjugation Modulation between Tetraphenylethene and Hemicyanine Moieties for Sensitive Detection of pH Changes in Live Cells.Bioconjugate chemistry · 2018Article
- Chemical Biology of HChemical reviews · 2018Review
- Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling.Antioxidants & redox signaling · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydropersulfide (R-SSH) is an important class of reactive sulfur species (RSS) involved in a variety of physiological processes in mammals. A fluorescent probe capable of real-time detection of hydropersulfide levels in living cells would be a versatile tool to elucidate its roles in cell signalling and redox homeostasis. In this paper, we report a ratiometric fluorescent probe for hydropersulfide sensing, based on a fluorescence resonance energy transfer (FRET) mechanism. This sensing mechanism involves a nucleophilic reaction of a hydropersulfide with the pyronine-unit of the probe, which modulates the intramolecular FRET efficiency to induce a dual-emission change. The reversible nature of this reaction allows us to detect increases and decreases of hydropersulfide levels in a real-time manner. The probe fluorometrically sensed highly reactive hydropersulfides, such as H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.