ArticleChemical science2017
Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist.
Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Light-controlled inhibition of Gram-positive bacteria by photoswitchable amphiphilic lipids (PALs).RSC medicinal chemistry · 2026Article
- Reversible Control of Native GluN2B-Containing NMDA Receptors with Visible Light.ACS chemical neuroscience · 2024Article
- Light-Sensitive Open Channel Block of Ionotropic Glutamate Receptors by Quaternary Ammonium Azobenzene Derivatives.International journal of molecular sciences · 2023Article
- Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects.Biomolecules · 2022Review
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Molecular photoswitches in aqueous environments.Chemical Society reviews · 2021Review
- Pyrrole Hemithioindigo Antimitotics with Near-Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single-Cell Precision*.Angewandte Chemie (International ed. in English) · 2021Article
- Optical control of purinergic signaling.Purinergic signalling · 2021Review
- Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.Chemical reviews · 2020Article
- Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders.Frontiers in synaptic neuroscience · 2020Review
- The next generation of approaches to investigate the link between synaptic plasticity and learning.Nature neuroscience · 2019Review
- Optical control of neuronal ion channels and receptors.Nature reviews. Neuroscience · 2019Review
- Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Photochemical Control of Protein Arginine Deiminase (PAD) Activity.ACS chemical biology · 2018Article
- Precise modulation of neuronal activity with synthetic photoswitchable ligands.Current opinion in neurobiology · 2017Review
- Synapses in the spotlight with synthetic optogenetics.EMBO reports · 2017Review
- Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo.Brain stimulationArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
AMPA receptors respond to the neurotransmitter glutamate and play a critical role in excitatory neurotransmission. They have been implicated in several psychiatric disorders and have rich pharmacology. Antagonists of AMPA receptors have been explored as drugs and one has even reached the clinic. We now introduce a freely diffusible photoswitchable antagonist that is selective for AMPA receptors and endows them with light-sensitivity. Our photoswitch,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.