Evidence map›Paper›PMID 28451145›Full record

ArticleChemical science2016

Competitive method-based electrochemiluminescent assay with protein-nucleotide conversion for ratio detection to efficiently monitor the drug resistance of cancer cells.

Wen-Bin Liang, Ming-Zhen Yang, Ying Zhuo, Ying-Ning Zheng, Cheng-Yi Xiong, Ya-Qin Chai, Ruo Yuan

Abstract read
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen-Bin LiangKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) , Ministry of Education , College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: yqchai@swu.edu.cn ; Email: yuanruo@swu.edu.cn.
Ming-Zhen YangDepartment of Clinical Biochemistry , Laboratory Sciences , Southwest Hospital , Third Military Medical University , 30 Gaotanyan Street, Shapingba District , Chongqing 400038 , PR China.
Ying ZhuoKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) , Ministry of Education , College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: yqchai@swu.edu.cn ; Email: yuanruo@swu.edu.cn.
Ying-Ning ZhengKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) , Ministry of Education , College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: yqchai@swu.edu.cn ; Email: yuanruo@swu.edu.cn.
Cheng-Yi XiongKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) , Ministry of Education , College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: yqchai@swu.edu.cn ; Email: yuanruo@swu.edu.cn.
Ya-Qin ChaiKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) , Ministry of Education , College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: yqchai@swu.edu.cn ; Email: yuanruo@swu.edu.cn.
Ruo YuanKey Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University) , Ministry of Education , College of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , PR China . Email: yqchai@swu.edu.cn ; Email: yuanruo@swu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A simple and highly-efficient approach to monitor the expression of P-glycoprotein (P-gp) in cells was urgently needed to demonstrate the drug resistance of cancer cells. Herein, a competitive method-based electrochemiluminescent (ECL) assay with a single ECL indicator was proposed for the first time to efficiently estimate the concentration ratio of two proteins. By converting the different proteins to partially coincident nucleotide sequences

Identifiers

PMID28451145
PMCPMC5355943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.