Evidence map›Paper›PMID 28451062›Full record

ArticleWorld journal of gastrointestinal oncology2017

Effect of

Zheng-Yun Liang, Xing Kang, Hong Chen, Meng Wang, Wen-Xian Guan

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastrointestinal oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Claudin-4: A New Molecular Target for Epithelial Cancer Therapy.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Review
  6. Targeting claudins in cancer: diagnosis, prognosis and therapy.American journal of cancer research · 2021
    Review
  7. Article
  8. Race, the microbiome and colorectal cancer.World journal of gastrointestinal oncology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Zheng-Yun LiangZheng-Yun Liang, Department of General Surgery, Qianxinan People's Hospital, Xingyi 562400, Guizhou Province, China.
Xing KangZheng-Yun Liang, Department of General Surgery, Qianxinan People's Hospital, Xingyi 562400, Guizhou Province, China.
Hong ChenZheng-Yun Liang, Department of General Surgery, Qianxinan People's Hospital, Xingyi 562400, Guizhou Province, China.
Meng WangZheng-Yun Liang, Department of General Surgery, Qianxinan People's Hospital, Xingyi 562400, Guizhou Province, China.
Wen-Xian GuanZheng-Yun Liang, Department of General Surgery, Qianxinan People's Hospital, Xingyi 562400, Guizhou Province, China.
Nanjing Drum Tower Hospital · CNCreative Research Enterprises (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effects of

methodsIn this study, we detected expression of CL4 protein in different gastric cancer cell lines. Then, we investigated the effects of CPE on SGC7901 cells which highly expressed CL4 protein and the effects of CPE on subcutaneous tumor in nude mice models.

resultsCL4 are highly expressed in SGC7901 cells. CPE expressed significant cytotoxicity in SGC7901 cells. Suppression of CL4 expression significantly decreased CPE-mediated cytotoxicity. CPE also inhibited tumor growth in subcutaneous tumor xenograft models.

conclusionCPE showed CL4 mediated cytotoxicity on gastric cancer cells SGC7901 and inhibited tumor growth in nude mice models.

Indexed as

Claudin-4 proteinClostridium perfringens enterotoxinCytotoxicityGastric cancerTight junction

Identifiers

PMID28451062
PMCPMC5390300
OpenAlexW2604215483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.