Evidence map›Paper›PMID 28450911›Full record

ArticleExperimental and therapeutic medicine2017

Propofol inhibits expression of angiotensin II receptor type 2 in dorsal root ganglion neurons.

Bingbing Pan, Zhigang Cheng, Gaoyin Kong, Zongbin Song, Yunjiao Wang, Lai Wei, Dan Xiao, Yuan Zhao, Qulian Guo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bingbing PanDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China.
Zhigang ChengDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China.
Gaoyin KongDepartment of Anesthesiology, Hunan Provincial People's Hospital, Changsha, Hunan 410001, P.R. China.
Zongbin SongDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China.
Yunjiao WangDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China.
Lai WeiDepartment of Anesthesiology, Hunan Provincial People's Hospital, Changsha, Hunan 410001, P.R. China.
Dan XiaoDepartment of Anesthesiology, Hunan Provincial People's Hospital, Changsha, Hunan 410001, P.R. China.
Yuan ZhaoDepartment of Anesthesiology, Hunan Provincial People's Hospital, Changsha, Hunan 410001, P.R. China.
Qulian GuoDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China.
Central South University · CNHunan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The renin-angiotensin system (RAS) is involved in nociception and has functions in the cardiovascular system. The primary role of the RAS is to mediate the effect of angiotensin II (Ang II) through Ang II receptor type 2 (AT2). Due to this, AT2 has become a novel therapeutic target for the relief of peripheral neuropathic pain in humans. As it is one of the most popular induction agents of general anesthesia, propofol also exerts peripheral antinociceptive effects. The present study assessed the effect of propofol on the expression of AT2 in cultured dorsal root ganglion (DRG) neurons. The results indicate that propofol decreases

Indexed as

angiotensin IIangiotensin II receptor type 1angiotensin II receptor type 2dorsal root ganglionphosphatidylinositol 3-kinasepropofol

Identifiers

PMID28450911
PMCPMC5403460
OpenAlexW2579627258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.