Evidence map›Paper›PMID 28450909›Full record

ArticleExperimental and therapeutic medicine2017

Impact of gabapentin on neuronal high voltage-activated Ca

Minmin Zhu, Xiaodi Sun, Xiaodong Chen, Hang Xiao, Manlin Duan, Jianguo Xu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Gabapentin-Friend or foe?Pain practice : the official journal of World Institute of Pain · 2023
    Review
  3. Effect of PKC/NF-Pain research & management · 2020
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Minmin ZhuDepartment of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, P.R. China.
Xiaodi SunDepartment of Anaesthesiology, First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China.
Xiaodong ChenDepartment of Anaesthesiology, First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China.
Hang XiaoDepartment of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Manlin DuanDepartment of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, P.R. China.
Jianguo XuDepartment of Anaesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, P.R. China.
Nanjing Medical University · CNNanjing University · CNNanjing General Hospital of Nanjing Military Command · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The density and properties of ion channels in the injured axon and dorsal root ganglion (DRG) neuronal soma membrane change following nerve injury, which may result in the development of neuropathic pain. Gabapentin (GBP) is a drug for the first-line treatment of neuropathic pain. One of its therapeutic targets is the voltage-activated calcium channel (VACC). In the present study, the whole-cell patch clamp technique was used to examine the changes of high voltage-activated Ca

Indexed as

dorsal root gangliongabapentinhigh-voltage-activated Ca2+ channelspinal nerve ligation

Identifiers

PMID28450909
PMCPMC5403705
OpenAlexW2579208077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.