Evidence map›Paper›PMID 28450884›Full record

ArticleChinese medicine2017

Identification of anti-HBV activities in

Iao-Fai Lam, Min Huang, Margaret Dah-Tysr Chang, Pei-Wun Yao, Yu-Ting Chou, Sim-Kun Ng, Ying-Lin Tsai, Yu-Chang Lin, Yun-Feng Zhang, Xiao-Yuan Yang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Chinese medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Iao-Fai Lam *Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
Min Huang *Yunnan Baiyao-Herbcopoeia Laboratory Inc., 51 Xi-Ba Road, Kunming, Yunnan China.
Margaret Dah-Tysr ChangInstitute of Molecular and Cellular Biology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
Pei-Wun YaoInstitute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
Yu-Ting ChouInstitute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
Sim-Kun NgInstitute of Molecular and Cellular Biology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
Ying-Lin TsaiInstitute of Molecular and Cellular Biology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
Yu-Chang LinInstitute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
Yun-Feng ZhangSchool of Life Science, Yunnan Normal University, Kunming, Yunnan China.
Xiao-Yuan YangYunnan Baiyao-Herbcopoeia Laboratory Inc., 51 Xi-Ba Road, Kunming, Yunnan China.
Yiu-Kay LaiInstitute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
National Tsing Hua University · TWYunnan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHerbochip

methodsWe cloned and expressed a truncated but fully functional form of human GRP78 (hGRP78

resultsPrimary screenings using GRP78 on 40 herbochips revealed 11 positives. Four of the positives, namely

conclusionWe have demonstrated that GRP78 is a valid probe for anti-HBV drug screening on herbochips. We have also shown that PSE, while being non-cytotoxic, possesses in vitro and in vivo anti-HBV activities. Taken together, our data suggest that PSE may be a potential anti-HBV agent for therapeutic use.

Indexed as

Anti-HBVGRP78HerbochipMoutan Cortex RadicisPaeoniaceaePaeonia suffruticosa

Identifiers

PMID28450884
PMCPMC5402670
OpenAlexW2608149054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.