Evidence map›Paper›PMID 28450854›Full record

ArticleFrontiers in microbiology2017

Microbial Disease Spectrum Linked to a Novel IL-12Rβ1 N-Terminal Signal Peptide Stop-Gain Homozygous Mutation with Paradoxical Receptor Cell-Surface Expression.

Thais Louvain de Souza, Regina C de Souza Campos Fernandes, Juliana Azevedo da Silva, Vladimir Gomes Alves Júnior, Adelia Gomes Coelho, Afonso C Souza Faria, Nabia M Moreira Salomão Simão, João T Souto Filho, Caroline Deswarte, Stéphanie Boisson-Dupuis and 4 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Cytokine Receptors-Regulators of Antimycobacterial Immune Response.International journal of molecular sciences · 2022
    Review
  4. Review
  5. Histoplasmosis in Children; HIV/AIDS Not a Major Driver.Journal of fungi (Basel, Switzerland) · 2021
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. The Child with Recurrent Mycobacterial Disease.Current allergy and asthma reports · 2018
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Thais Louvain de SouzaNúcleo de Diagnóstico e Investigação Molecular, Laboratório de Biotecnologia, Universidade Estadual do Norte FluminenseCampos dos Goytacazes, Brazil.
Regina C de Souza Campos FernandesNúcleo de Diagnóstico e Investigação Molecular, Laboratório de Biotecnologia, Universidade Estadual do Norte FluminenseCampos dos Goytacazes, Brazil.
Juliana Azevedo da SilvaLaboratório de Biologia do Reconhecer, Universidade Estadual do Norte FluminenseCampos dos Goytacazes, Brazil.
Vladimir Gomes Alves JúniorNúcleo de Diagnóstico e Investigação Molecular, Laboratório de Biotecnologia, Universidade Estadual do Norte FluminenseCampos dos Goytacazes, Brazil.
Adelia Gomes CoelhoHospital Municipal Ferreira MachadoCampos dos Goytacazes, Brazil.
Afonso C Souza FariaPronto Atendimento UNIMEDCampos dos Goytacazes, Brazil.
Nabia M Moreira Salomão SimãoHospital Escola Álvaro AlvimCampos dos Goytacazes, Brazil.
João T Souto FilhoFaculdade de Medicina de CamposCampos dos Goytacazes, Brazil.
Caroline DeswarteLaboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche MédicaleParis, France.
Stéphanie Boisson-DupuisLaboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche MédicaleParis, France.
Dara TorgersonDepartment of Medicine, University of California San FranciscoSan Francisco, CA, USA.
Jean-Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche MédicaleParis, France.
Jacinta BustamanteLaboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche MédicaleParis, France.
Enrique Medina-AcostaNúcleo de Diagnóstico e Investigação Molecular, Laboratório de Biotecnologia, Universidade Estadual do Norte FluminenseCampos dos Goytacazes, Brazil.
Prefeitura Municipal de Campos dos Goytacazes · BRState University of Norte Fluminense · BRInstitut de Génétique Humaine · FRInstitut des Maladies Génétiques Imagine · FRRockefeller University · USUniversité Paris Cité · FRUniversity of California, San Francisco · US

Funding

Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial DiseaseR37AI095983 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT · 2011 to 2020
$4.6M
NIAID NIH HHS R37 AI095983
6 · The paper itself

Abstract

Patients with Mendelian Susceptibility to Mycobacterial Diseases (MSMD) exhibit variable vulnerability to infections by mycobacteria and other intramacrophagic bacteria (e.g.,

Indexed as

founder stop-gain mutationIFN-γIL-12Rβ1 deficiencyimpaired receptorMendelian susceptibility to mycobacterial diseasessignal peptide

Identifiers

PMID28450854
PMCPMC5389975
OpenAlexW2605987144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.