Evidence map›Paper›PMID 28450637›Full record

ArticleScience (New York, N.Y.)2017

Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly.

George Mountoufaris, Weisheng V Chen, Yusuke Hirabayashi, Sean O'Keeffe, Maxime Chevee, Chiamaka L Nwakeze, Franck Polleux, Tom Maniatis

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 189 citations in OpenAlex.

  1. WAVE2 and REST/NRSF Regulate Clustered Gene Expression by Maintaining Heterochromatin Organization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
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  11. Structural Insights into Ordered Multicomponent Assemblies in Cell Junctions.Advances in experimental medicine and biology · 2026
    Review
  12. Article
  13. Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
  16. Nervous system-wide analysis of allScience advances · 2025
    Article
  17. Article
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  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

George MountoufarisDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-0240-9745
Weisheng V ChenDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-5546-8933
Yusuke HirabayashiMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA.
Sean O'KeeffeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-0971-1525
Maxime CheveeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-2385-3757
Chiamaka L NwakezeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-5243-8491
Franck PolleuxMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-4313-0481
Tom ManiatisDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. tm2472@cumc.columbia.edu.ORCID 0000-0002-2722-8633
Columbia University · USAllen Institute for Brain Science · US

Funding

TRAINING IN CELLULAR, MOLECULAR AND BIOPHYSICAL STUDIEST32GM008224 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LIEM, RONALD K. · 1987 to 2021
$9.9M
The role of the clustered protocadherins in neural circuit formation and implications for neurodevelopmental disordersR01MH108579 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P · 2016 to 2025
$5.1M
A kinase pathway required for terminal axon branching and presynaptic functionR01NS089456 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI POLLEUX, FRANCK · 2014 to 2017
$1.6M
The Role of Clustered Protocadherins in Neurite Self-avoidanceR01NS088476 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P · 2015 to 2018
$1.5M
Single Cell Studies of Lineage Specific Expression of the Protocadherin Gene ClusR21NS088992 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P · 2014 to 2015
$440k
NIGMS NIH HHS T32 GM008224NIMH NIH HHS R01 MH108579NINDS NIH HHS R01 NS088476NINDS NIH HHS R01 NS089456NINDS NIH HHS R21 NS088992
6 · The paper itself

Abstract

The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (

Indexed as

AnimalsAxonsCadherinsGene DeletionGene ExpressionGenetic VariationMiceMice, Inbred C57BLMultigene FamilyNerve NetNeurogenesisOlfactory Receptor NeuronsVesicular Glutamate Transport Protein 2CadherinsSlc17a6 protein, mouseVesicular Glutamate Transport Protein 2

Identifiers

PMID28450637
PMCPMC5529182
OpenAlexW2609422947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.