Evidence map›Paper›PMID 28450636›Full record

ArticleScience (New York, N.Y.)2017

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.

Weisheng V Chen, Chiamaka L Nwakeze, Christine A Denny, Sean O'Keeffe, Michael A Rieger, George Mountoufaris, Amy Kirner, Joseph D Dougherty, René Hen, Qiang Wu and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 167 citations in OpenAlex.

  1. Article
  2. System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Weisheng V ChenDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-5546-8933
Chiamaka L NwakezeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-5243-8491
Christine A DennyDepartment of Psychiatry, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-6926-2020
Sean O'KeeffeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-0971-1525
Michael A RiegerDepartments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4020-5476
George MountoufarisDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-0240-9745
Amy KirnerDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-1456-6107
Joseph D DoughertyDepartments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6385-3997
René HenDepartment of Psychiatry, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-7763-4162
Qiang WuCenter for Comparative Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Tom ManiatisDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. tm2472@cumc.columbia.edu.ORCID 0000-0002-2722-8633
Columbia University · USResearch Foundation For Mental Hygiene · USWashington University in St. Louis · USShanghai Jiao Tong University · CN

Funding

TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
TRAINING IN CELLULAR, MOLECULAR AND BIOPHYSICAL STUDIEST32GM008224 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LIEM, RONALD K. · 1987 to 2021
$9.9M
The role of the clustered protocadherins in neural circuit formation and implications for neurodevelopmental disordersR01MH108579 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P · 2016 to 2025
$5.1M
Translational Neuroscience Training Grant.T32MH015174 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DENNY, CHRISTINE ANN · 1985 to 2020
$4.0M
The Role of Clustered Protocadherins in Neurite Self-avoidanceR01NS088476 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P · 2015 to 2018
$1.5M
MASSIVELY PARALLEL CHARACTERIZATION OF CIS-REGULATORY ELEMENTS IN THE BRAINR01HG008687 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A · 2015 to 2017
$1.1M
Use of induced pluripotent stem cells to study mechanims of familial and sporadicDP1NS082099 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P · 2012 to 2012
$797k
Single Cell Studies of Lineage Specific Expression of the Protocadherin Gene ClusR21NS088992 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P · 2014 to 2015
$440k
NHGRI NIH HHS R01 HG008687NIGMS NIH HHS T32 GM007067NIGMS NIH HHS T32 GM008224NIMH NIH HHS R01 MH108579NIMH NIH HHS T32 MH015174NINDS NIH HHS DP1 NS082099NINDS NIH HHS R01 NS088476NINDS NIH HHS R21 NS088992
6 · The paper itself

Abstract

Serotonergic neurons project their axons pervasively throughout the brain and innervate various target fields in a space-filling manner, leading to tiled arrangements of their axon terminals to allow optimal allocation of serotonin among target neurons. Here we show that conditional deletion of the mouse protocadherin α (

Indexed as

AnimalsAxonsCadherinsDepressionGene DeletionLimbic SystemMiceMice, Mutant StrainsMultigene FamilySerotonergic NeuronsSerotoninCadherinsPcdhalphac2 protein, mouseSerotonin

Identifiers

PMID28450636
PMCPMC5529183
OpenAlexW2608960550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.