Evidence map›Paper›PMID 28450535›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Sodium Channel Na

Amanda H Klein, Alina Vyshnevska, Timothy V Hartke, Roberto De Col, Joseph L Mankowski, Brian Turnquist, Frank Bosmans, Peter W Reeh, Martin Schmelz, Richard W Carr and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Extended local anesthesia enabled by flavonoid permeation enhancers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Review
  7. Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  12. Studying human nociceptors: from fundamentals to clinic.Brain : a journal of neurology · 2021
    Review
  13. Review
  14. Article
  15. A Novel Single-Domain NaPlant physiology · 2020
    Article
  16. Ablation of sensory nerves favours melanoma progression.Journal of cellular and molecular medicine · 2020
    Article
  17. Enhancement by TNF-α of TTX-resistant NaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Amanda H KleinDepartment of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287.ORCID 0000-0002-3433-2180
Alina VyshnevskaDepartment of Anaesthesiology and Operative Intensive Care, University of Heidelberg, 68167 Mannheim, Germany.
Timothy V HartkeDepartment of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287.
Roberto De ColDepartment of Anaesthesiology and Operative Intensive Care, University of Heidelberg, 68167 Mannheim, Germany.
Joseph L MankowskiDepartment of Molecular and Comparative Pathobiology and.ORCID 0000-0002-6283-4727
Brian TurnquistDepartment of Mathematics and Computer Science, Bethel University, St. Paul, Minnesota 55112, and.ORCID 0000-0002-9988-2116
Frank BosmansDepartment of Physiology and Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205.
Peter W ReehInstitute of Physiology and Pathology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.ORCID 0000-0002-4367-094X
Martin SchmelzDepartment of Anaesthesiology and Operative Intensive Care, University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0002-9736-7241
Richard W CarrDepartment of Anaesthesiology and Operative Intensive Care, University of Heidelberg, 68167 Mannheim, Germany, Richard.Carr@medma.uni-heidelberg.de platelet@jhmi.edu.ORCID 0000-0001-8617-9133
Matthias RingkampDepartment of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, Richard.Carr@medma.uni-heidelberg.de platelet@jhmi.edu.
Johns Hopkins University · USUniversity of Mannheim · DEBethel University · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHeidelberg University · DE

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Viral Testing CoreU42OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2017 to 2026
$10.9M
Development of an SPF Macaca nemestrina Breeding ColonyP40OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI ADAMS, ROBERT J. · 2012 to 2016
$4.9M
SIV-induced Inflammation Causes Functional Impairment of the PNSR01NS097221 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MANKOWSKI, JOSEPH L, RINGKAMP, MATTHIAS · 2016 to 2020
$3.7M
Mechanisms of analgesia by peripheral viral vector insertion of opioid receptors.F32DA036991 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KLEIN, AMANDA HELEN · 2014 to 2014
$38k
NCATS NIH HHS UL1 TR001079NIDA NIH HHS F32 DA036991NIH HHS P40 OD013117NIH HHS U42 OD013117NINDS NIH HHS R01 NS097221
6 · The paper itself

Abstract

Voltage-gated sodium (Na

Indexed as

Afferent PathwaysAnimalsAxonsIon Channel GatingMacaca nemestrinaMaleNAV1.8 Voltage-Gated Sodium ChannelNerve Fibers, UnmyelinatedNeural ConductionPeripheral NervesSkinSkin Physiological PhenomenaTetrodotoxinVoltage-Gated Sodium Channel BlockersNAV1.8 Voltage-Gated Sodium ChannelTetrodotoxinVoltage-Gated Sodium Channel Blockersnociceptornonhuman primatepainsodium channels

Identifiers

PMID28450535
PMCPMC5444201
OpenAlexW2608037183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.