Evidence map›Paper›PMID 28450459›Full record

ArticleGenetics2017

Experimental Evolution Reveals Favored Adaptive Routes to Cell Aggregation in Yeast.

Elyse A Hope, Clara J Amorosi, Aaron W Miller, Kolena Dang, Caiti Smukowski Heil, Maitreya J Dunham

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Protein structure shapes natural genetic variation andbioRxiv : the preprint server for biology · 2025
    Article
  5. Overcoming toxicity: How nonantagonistic microbes manage to thrive in boom-and-bust environments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Long-term evolution of proliferating cells using the eVOLVER platform.bioRxiv : the preprint server for biology · 2023
    Article
  10. Article
  11. Parallel Evolution in PredatoryApplied and environmental microbiology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elyse A HopeDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195.ORCID 0000-0002-9026-9788
Clara J AmorosiDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195.
Aaron W MillerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195.
Kolena DangDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195.
Caiti Smukowski HeilDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195.
Maitreya J DunhamDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195 maitreya@uw.edu.ORCID 0000-0001-9944-2666
University of Washington · US

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
NHGRI NIH HHS T32 HG000035NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

Yeast flocculation is a community-building cell aggregation trait that is an important mechanism of stress resistance and a useful phenotype for brewers; however, it is also a nuisance in many industrial processes, in clinical settings, and in the laboratory. Chemostat-based evolution experiments are impaired by inadvertent selection for aggregation, which we observe in 35% of populations. These populations provide a testing ground for understanding the breadth of genetic mechanisms

Indexed as

Directed Molecular EvolutionGenetics, PopulationCell AggregationDNA Transposable ElementsFlocculationMannose-Binding LectinsNuclear ProteinsPhenotypePromoter Regions, GeneticRepressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence DeletionDNA Transposable ElementsFLO1 protein, S cerevisiaeMannose-Binding LectinsNuclear ProteinsRepressor ProteinsSaccharomyces cerevisiae ProteinsTUP1 protein, S cerevisiaeexperimental evolutionFLO1flocculationyeast, chemostat

Identifiers

PMID28450459
PMCPMC5499169
OpenAlexW2953269506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.