Observational studyAJNR. American journal of neuroradiology2017
Characterization of Extensive Microstructural Variations Associated with Punctate White Matter Lesions in Preterm Neonates.
Observational study in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy and safety of Niaoduqing granules in the treatment of diabetic kidney disease: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Risk factors for neonatal brain injury in neonates born to mothers with preeclampsia: a retrospective study.BMC pregnancy and childbirth · 2026Article
- Structural and functional connectivity of the brain in premature infants with non-hemorrhagic punctate white matter lesions: a graph analysis.Pediatric radiology · 2026Article
- Prenatal Opioid Exposure Is Associated with Punctate White Matter Lesions in Term Newborns.The Journal of pediatrics · 2025Observational
- The Value of Diffusion Kurtosis Imaging in Detecting Delayed Brain Development of Premature Infants.Frontiers in neurology · 2021Article
- Exploring Variances of White Matter Integrity and the Glymphatic System in Simple Febrile Seizures and Epilepsy.Frontiers in neurology · 2021Article
- Inter-site harmonization based on dual generative adversarial networks for diffusion tensor imaging: application to neonatal white matter development.Biomedical engineering online · 2020Article
- Detection of occult abnormalities in the deep gray matter nuclei of neonates with punctate white matter lesions by magnetic resonance spectroscopy.Neuroradiology · 2019Article
- Observational
- Assessment of myelination progression in subcortical white matter of children aged 6-48 months using T2-weighted imaging.Neuroradiology · 2018Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePunctate white matter lesions are common in preterm neonates. Neurodevelopmental outcomes of the neonates are related to the degree of extension. This study aimed to characterize the extent of microstructural variations for different punctate white matter lesion grades. MATERIALS AND
methodsPreterm neonates with punctate white matter lesions were divided into 3 grades (from mild to severe: grades I-III). DTI-derived fractional anisotropy, axial diffusivity, and radial diffusivity between patients with punctate white matter lesions and controls were compared with Tract-Based Spatial Statistics and tract-quantification methods.
resultsThirty-three preterm neonates with punctate white matter lesions and 33 matched controls were enrolled. There were 15, 9, and 9 patients, respectively, in grades I, II, and III. Punctate white matter lesions were mainly located in white matter adjacent to the lateral ventricles, especially regions lateral to the trigone, posterior horns, and centrum semiovale and/or corona radiata. Extensive microstructural changes were observed in neonates with grade III punctate white matter lesions, while no significant changes in DTI metrics were found for grades I and II. A pattern of increased axial diffusivity, increased radial diffusivity, and reduced/unchanged fractional anisotropy was found in regions adjacent to punctate white matter lesion sites seen on T1WI and T2WI. Unchanged axial diffusivity, increased radial diffusivity, and reduced/unchanged fractional anisotropy were observed in regions distant from punctate white matter lesion sites.
conclusionsWhite matter microstructural variations were different across punctate white matter lesion grades. Extensive change patterns varied according to the distance to the lesion sites in neonates with severe punctate white matter lesions. These findings may help in determining the outcomes of punctate white matter lesions and selecting treatment strategies.
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